Sexual Health
Dainippon Sumitomo Pharma Co., Ltd., (DSP) announced today positive results from the first phase 3 clinical trial for lurasidone, which is under clinical development globally, for the treatment of patients with schizophrenia. In this six-week, double-blind, placebo-controlled trial, lurasidone 80 mg/day was significantly more effective than placebo for the treatment of acute schizophrenia. In addition, lurasidone was well-tolerated and had a relatively low discontinuation rate. The findings were presented at the 162nd Annual Meeting of the American Psychiatric Association in San Francisco, held on May 16-21.
According to a new Mayo Clinic study, a history of child abuse significantly impacts the wide range of challenges facing depressed inpatients. Included are an increase in suicide attempts, prevalence of substance use disorder, and a higher incidence rate of personality disorder. Additionally, these victims also had an earlier onset of mental illness and an increase in psychiatric hospitalizations for psychiatric issues. The study was presented at the American Psychiatric Association 2009 Annual Meeting in San Francisco.
WellApps, Inc. launched an iPhone application to help people with (IBD) Crohn"s and Ulcerative Colitis provide accurate symptom data to their doctors for optimal treatment. The application, called GI Monitor , was developed by an 18-year Crohn"s patient after a recent flare up of his condition.
While young men with prostate cancer have a low risk of dying early, those with advanced forms of cancer do not live as long as older men with similar forms of the disease. That is the conclusion of a new study published in the July 1, 2009 issue of CANCER, a peer-reviewed journal of the American Cancer Society. The paradoxical findings indicate that there may be biological differences between prostate cancers that develop in younger men and those that develop in older men, and that uncovering these differences may help tailor screening and treatment strategies for patients based on age.
Leading pharmaceutical and biotech companies are drawing on Singapore"s
During a White House teleconference last week, Nancy-Ann DeParle, director of the White House Office on Health Reform said that reducing health care costs is "particularly important for the [black] community because on average, they spend a higher percentage of their income on health care costs, compared to their white counterparts," the Washington Informer reports. Nancy-Ann DeParle, director of the office, at a press conference last week said that reducing health care costs is "particularly important for the [black] community because on average, they spend a higher percentage of their income on health care costs, compared to their white counterparts." She added that blacks spend about 16.5% of their income on health care, while whites spend about 12%. In addition, blacks "continue to face disparities in terms of the (quality of care) they get," DeParle said. According to DeParle, blacks tend to visit hospitals that "provide lower-quality care." She added that higher health care costs are "especially troubling" to the black community because blacks "suffer from higher percentages of chronic diseases such as heart disease, kidney disease and diabetes, that are due in part to a lack of access to quality care."According to the Informer, $1 billion of the $787 billion stimulus package that President Obama signed in February will be allocated to prevention efforts and public health campaigns (Michaels, Washington Informer, 5/21).
Amid renewed calls to consider reducing the legal drinking age, a new University of Georgia study finds that lower drinking ages increase unplanned pregnancies and pre-term births among young people.
At six months, the NEVO™ Sirolimus-eluting Coronary Stent, incorporating RES Technology™, was superior to the Taxus® Liberte® Stent in reducing tissue growth within the stent that can potentially lead to repeat procedures, in new clinical study results released . In addition, no reports of stent thrombosis were reported in patients treated with NEVO™ through six months.
Women"s reproductive and lifestyle characteristics can be linked to different invasive breast cancer subtypes. Data on 2544 breast cancer cases, presented in the open access journal Breast Cancer Research, suggests that traditional risk factors for development of the condition are associated with different kinds of tumor.
Scientists have discovered that cells use a very simple phase transition -- similar to water vapor condensing into dew -- to assemble and localize subcellular structures that are involved in formation of the embryo.
New research provides exciting genetic insight into a rare syndrome that first appeared in the medical literature in the mid 1800s with the case of Julia Pastrana, the world"s most notorious bearded lady. The study, published by Cell Press in the May 21st issue of the American Journal of Human Genetics, reveals intriguing molecular clues about the pathogenesis of this mysterious condition that has captured the attention of the public since the Middle Ages.
Hypertension or high blood pressure is a condition in which the blood pressure in the arteries is chronically elevated. With every heart beat, the heart pumps blood through the arteries to the rest of the body. Blood pressure is the force of blood that is pushing up against the walls of the blood vessels. If the pressure is too high, the heart has to work harder to pump, and this could lead to organ damage and several illnesses such as heart attack, stroke, heart failure, aneurysm, or renal failure.
New research from the US suggests that people who drink from bottles made of polycarbonate plastic, such as that used to make hard-plastic
Type-2 diabetes patients who lose at least 5% of their body weight score significantly higher on health-related quality of life measures than those who gain 5%, according to a new Consumer Health Sciences (CHS) study presented today at the 14th Annual ISPOR (International Society for Pharmacoeconomic and Outcomes Research) Conference in Orlando, Florida. The benefits of weight loss are particularly dramatic for obese patients, who experience a sharp increase in quality of life scores with just a 5% weight reduction.
Dr. Reddy"s announced that the first human subjects were successfully dosed in a phase I study with DRL 17822, a selective inhibitor of CETP, for the treatment of dyslipidemia, atherosclerosis and associated cardiovascular diseases. The compound shows potent elevation in HDL-C and reduction of atherosclerotic plaques in animals, and has a clean safety profile in preclinical studies. The two other IND"s are for the treatment of COPD and dyslipidemia.
Cellceutix Corporation (OTCBB: CTIX), announced it has filed a U.S. patent application covering pharmaceutical formulations of a compound referred to as Kevetrin™ and many novel compounds having similar structures to Kevetrin. These structures cover a large number of compounds that Cellceutix can look at as possible drug development candidates. The application covers the use of Kevetrin™ and the other compounds in various areas, including cancers. Cellceutix plans to file in other countries within a year of the U.S. filing.
PolyMedix, Inc., an emerging biotechnology company developing acute care products for infectious diseases and acute cardiovascular disorders, has received a notice of no objection from Health Canada for the Company"s Clinical Trial Application ("CTA") for its defensin mimetic antibiotic compound, PMX-30063. This notice of no objection allows for the initiation of the second human clinical study in Canada. PMX-30063 is a defensin mimetic antibiotic compound, the first of an entirely new class of antibiotic drugs that is believed to work in such a way that makes bacterial resistance unlikely to develop.
On World Hepatitis Day, Concateno, a provider of drug testing and medical screening solutions, calls for the increased use of a broader range of Hepatitis testing techniques including dried blood spot and oral fluid testing. The company argues that these cost-effective and easy to use methods are often more convenient than collecting whole blood samples, and could significantly increase screening among injecting drug users (IDUs), one of the highest risk groups for infection.
Metabolic surgery, a new surgical approach to metabolic disease, may provide the key to curing diabetes in some patients. This data was presented at the American Association of Clinical Endocrinologists (AACE) 18th Annual Meeting & Clinical Congress.
Despite calamities from economic recessions, wars and famine to a flu epidemic afflicting the Earth, a new study from the University of Kansas and Gallup indicates that humans are by nature optimistic.
Women with ductal carcinoma in situ (DCIS) who exhibit an overexpression of the protein HER2/neu have a six-fold increase in risk of invasive breast cancer, according to a new study from the University of Pennsylvania School of Medicine. The results, published in the May issue of the journal Cancer Epidemiology, Biomarkers and Prevention, may help clinicians distinguish between DCIS that requires minimal treatment and DCIS that should be treated more aggressively.
Senate Finance Committee Chair Max Baucus (D-Mont.) on Thursday said that Congress" health care overhaul plan would cover 94% to 96% of the population but not undocumented immigrants, the AP/Las Vegas Sun reports (Alonso-Zaldivar, AP/Las Vegas Sun, 5/21). In remarks at a briefing sponsored by the Kaiser Family Foundation, Families USA and the National Federation of Independent Business, Baucus said, "There are always going to be some people ... you just can"t find" to enroll, adding that "we"re going to try to get as close as we can (to 100% coverage) and we"re working hard to accomplish that." He added, "[W]e"re not going to cover undocumented workers. That"s too politically explosive" (Reichard, CQ HealthBeat, 5/21). According to an analysis by the Center for Immigration Studies and the U.S. Census Bureau, undocumented immigrants make up between 15% and 22% of the estimated 47 million U.S. residents without health coverage. Baucus said, "I don"t have a good answer yet to undocumented workers, illegal aliens," adding, "There will still be charity care " (Landers, Dallas Morning News, 5/22). Baucus said that the bill his committee is working on and that he expects to mark up in mid-June will include "incentives" and possibly requirements for employers to pay for employee health insurance. Baucus mentioned the possibility of including an individual mandate and establishing a health insurance exchange (AP/Las Vegas Sun, 5/21). Baucus also noted that the plan most likely will include a public health insurance option in some form (Tumulty, "Swampland," Time Magazine, 5/21). "Everything"s on the table," Baucus said, warning that "because this is so big, so complex, there are going to be a lot of trade-offs. ... This is just so large" (CQ HealthBeat, 5/21). He said that he is very optimistic about the prospects of bipartisan support for the legislation, placing the odds at between 75% and 80% ("Swampland," Time Magazine, 5/21).
VIA Pharmaceuticals, Inc. (Nasdaq: VIAP), a biotechnology company focused on the development of compounds for the treatment of cardiovascular and metabolic disease, announced that it has completed enrollment in a Phase 2 clinical trial of its lead drug, VIA-2291 in patients who have experienced an acute coronary syndrome event such as a heart attack or unstable angina. The randomized, double blind, placebo-controlled study examines the impact of VIA-2291 on plaque inflammation as measured by Positron Emission Tomography with fluorodeoxyglucose tracer (FDG-PET), as well as other standard biomarkers of inflammation, over 24 weeks following such an acute event. A total of 52 patients have been enrolled in the study, which is expected to report data in the second half of 2009.
"Trends in Child Health 1997-2006: Assessing Racial/Ethnic Disparities in Unmet Dental Care Needs," Joint Center for Political and Economic Studies: The issue brief examines disparities in the reporting of unmet dental care needs because of cost over the past 12 months among black, Hispanic and white children younger than age 18. The brief compares the unmet dental care needs among the racial/ethnic groups of children overall and among children of various racial/ethnic groups in families with similar sociodemographic characteristics, such as family type, poverty status and health insurance coverage. Hispanic children are the most likely to have dental care needs that are unmet because of cost, according to the brief. In addition, the brief analyzes several indicators of child health -- including low birthweight, health status, unmet dental care needs, ADHD/ADD diagnosis and asthma diagnosis -- to provide additional details of disparities in child health (Joint Center for Political and Economic Studies, May 2009).
It is the concentration of a few signaling molecules that determines the fate of individual cells during the early development of organisms. In the renowned journal Current Biology, a team of molecular biologists led by Pia Aanstad of the University of Innsbruck reports that a variety of molecular mechanisms accounts for the interpretation of the concentration of the signaling molecule Hedgehog.
The latest special issue of Science in China Series C: Life Sciences focuses on the recent progress in the H5N1-related research field.
Today sees the European launch of the first topical calcineurin inhibitor to be approved for the maintenance treatment of eczema to prevent flares and prolong flare-free intervals. PROTOPIC ointment (tacrolimus monohydrate) is already licensed to treat moderate and severe eczema (atopic dermatitis), often involving the treatment of flares as and when they occur.* It is now also approved for twice-weekly application to previously affected skin to prevent these exacerbations and prolong flare-free periods in PROTOPIC-responsive patients.ò€ Clinical studies have shown that this new approach brings significant benefits with over 40% of patients with moderate to severe eczema remaining flare-free for at least a year.1 Flares are known to place an enormous burden on patients. The International Study of Life with Atopic Eczema (ISOLATE) found that about 55% of these patients worried about the onset of their next exacerbation and that they spent on average over a third of the year (136 days) with their eczema in flare.2
Women who are at risk for heart disease and who are also experiencing menopause symptoms now have an added re - a highly specialized clinic in the Division of Cardiology at the Cedars-Sinai Heart Institute. The Advanced Preventive Women"s Clinic at the Women"s Heart Center recently opened and is offering comprehensive cardiac risk assessments designed specifically for women who are in menopause. The clinic also offers menopausal patients state-of-the-art screenings, as well as personalized medicine therapies and counseling, including high-risk hormone counseling.
Couples are being asked to replace their usual form of birth control with a new male contraceptive in a study to test its effectiveness.
A new Cochrane Library review confirms that years-long use of a drug called rituximab extends the lifespan of people with one of the milder forms of lymphoma.
Today, Baxter is announcing that its investigation of reports from Beebe Medical Center has determined that the three patient events are unrelated to product quality involving the company"s heparin premix products.
Since 2000, nearly 1,000 "retail clinics" -- offering routine care like sports physicals and immunizations and treatment for minor illnesses like strep throat -- have opened their doors inside pharmacies and grocery stores across the United States. Retail chain operators proposed that the new clinics would improve access to medical care among uninsured or underserved populations. However, these clinics have been opened more often in higher-income areas that are less likely to be classified as medically underserved, according to a new study from the University of Pennsylvania School of Medicine published in the May 25 issue of Archives of Internal Medicine.
Inflammation could contribute to bone loss in Duchenne"s muscular dystrophy (DMD), a discovery made by a group of Italian researchers. Dr Anna Rufo and her colleagues found that levels of an inflammatory molecule, known as IL-6, are high in patients with DMD.
UroToday.com - Cigarette smoking is a major risk factor for renal cell carcinoma (RCC). Cigarette smoke contains a variety of carcinogenic chemicals such as polycyclic aromatic hydrocarbons, aromatic amines, heterocyclic aromatic amines and N-nitrosamines. Among the N-nitrosamines present in cigarette smoke, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is the most abundant and the most potent in terms of carcinogenicity.
Most women who are likely to have a bone fracture do not think they are at greater risk, said a leading Italian rheumatologist at a European conference today. This could help to explain why many women do not adhere to preventive treatment.
The European Union readily brings to mind rules and regulations regarding everything from the shape of a cucumber to the generation of statistics. The EU"s formal regulations consist of more than 300,000 legal documents. However, a new dissertation in business studies at Stockholm University shows that, in practice, the regulation of the EU is much more comprehensive than that.
The National Association of Chain Drug Stores (NACDS) announced its ECON 09 Business Programs for the 2009 Marketplace Conference, to be held June 28-July 1 in Boston, Massachusetts. The presentations are new additions to the Marketplace program.
A heart muscle protein can replace its missing skeletal muscle counterpart to give mice with myopathy a long and active life, show Nowak et al. The findings were published online on May 25, 2009 (http://www.jcb.org) and will appear in the June 1, 2009 print issue of the Journal of Cell Biology.
Rhabdomyosarcoma (RMS) is an aggressive muscle cancer that mostly affects children. The most common forms of RMS are embryonal rhabdomyosarcoma (ERMS) and alveolar rhabdomyosarcoma (ARMS). Although ARMS is less common than ERMS, it is associated with a much higher rate of mortality. A therapy tailored to the ARMS form of RMS is therefore badly needed. A team of researchers, at the Hospital for Sick Children, Toronto, and Monash Institute of Medical Research, Australia, has now provided hope that it might be possible to develop such a therapy by showing that the protein ILK promotes the growth of ARMS cells, whereas it suppresses the growth of ERMS cells.
Two hundred physical therapists, physical therapist assistants, and students of physical therapy marched on Capitol Hill Tuesday to educate lawmakers about the critical need for patients to have improved access to physical therapy services. The group-members of the American Physical Therapy Association (APTA)-conducted approximately 350 visits with Representatives and Senators.
Children of parents who refuse vaccines are 23 times more likely to get whooping cough compared to fully immunized children, according to a new study led by a vaccine research team at Kaiser Permanente Colorado"s Institute for Health Research.
Neurosensory diseases are difficult to model in mice because their symptoms are complex and diverse. The genetic causes identified are often lethal when transferred to a mouse. The lack of animal models slows progress in understanding and treating the diseases. By strategically altering a protein-making molecule, a mouse was made to help understand nervous system diseases that impair feeling and cause paralysis of the arms and legs in humans.
As thousands of students nationwide prepare to leave high school, a UC Davis study appearing online in the June issue of the medical journal Pediatrics shows a clear link between attention problems early in school - as early as kindergarten - and lower high school test scores.
The Rural Doctors Association of Australia (RDAA) says two country doctors" skills last Friday-in saving
The Government today responded to the independent inquiry into contaminated blood supplies in the 1970s and 1980s.
At a time when the drug industry is striving for patient-friendly delivery methods for new and existing drugs, the growing availability of innovative inhaler device designs is driving interest in pulmonary drug delivery technology and devices as an alternative to oral and parenteral routes of administration. While well-established for treating upper respiratory diseases such as asthma and COPD, companies competing in the inhaled drug delivery sector - major players such as GlaxoSmithKline, AstraZeneca and Boehringer Ingelheim as well as pure-play start-ups - continue to view delivery of systemic drugs via inhalation as a major opportunity.
Definiens, the number one Enterprise Image Intelligence® company, announced that Moffitt Cancer Center will utilize Definiens technology in the analysis of lung cancer CT images for the purpose of developing more accurate prognosis and prediction models for response to specific lung cancer therapies. Image features extracted with Definiens technology will be compared to disease outcomes, as well as gene expression data available through Total Cancer CareTM, Moffitt"s comprehensive approach to cancer that enables researchers and caregivers to identify and meet all the needs of a patient and their family during the patient"s lifetime and for future generations.
Ark Therapeutics Group plc ("Ark" or the "Company") announces that the first patient has been enrolled into the US Phase III study for Trinam®. Trinam® is Ark"s novel gene-based medicine to prevent blood vessels blocking in kidney dialysis patients who have undergone vascular access graft surgery. The product is an adenovirus-mediated VEGF D gene delivered with a novel biodegradeable local delivery device (EG001).
American Science and Engineering, Inc. (NASDAQ: ASEI) (AS&E®), a leading worldwide supplier of innovative X-ray inspection solutions, announced the Company has been named to The Boston Globe"s "Globe 100" list of top performing public companies in Massachusetts.
AARP Executive Vice President Nancy LeaMond
Researchers from around the world will present the latest breakthroughs in electro-optics, lasers and the application of light waves at the 2009 Conference on Lasers and Electro-Optics/International Quantum Electronics Conference (CLEO/IQEC) May 31 to June 5 at the Baltimore Convention Center in Baltimore.
There are several risk factors for the development of Alzheimer"s disease and vascular dementia. Based on an increasing number of studies linking these risk factors with Vitamin D deficiency, an article in the current issue of the Journal of Alzheimer"s Disease (May 2009) by William B. Grant, PhD of the Sunlight, Nutrition, and Health Research Center (SUNARC) suggests that further investigation of possible direct or indirect linkages between Vitamin D and these dementias is needed.
It is estimated that up to 30 percent of all people who have surgery experience gastrointestinal side effects, such as nausea and vomiting. The use of opioid pain medicines during and after surgery is a leading risk factor for experiencing these side effects. Nausea and vomiting are uncomfortable and bothersome and can have an impact on a patient"s recovery.
Mayo Clinic researchers are reporting positive results in early leukemia clinical trials using the chemical epigallocatechin gallate (EGCG), an active ingredient in green tea. The trial determined that patients with chronic lymphocytic leukemia (CLL) can tolerate the chemical fairly well when high doses are administered in capsule form and that lymphocyte count was reduced in one-third of participants. The findings appear today online in the Journal of Clinical Oncology.
The key to reducing the leading cause of pediatric emergency room visits could be to educate young patients and their parents about how to manage asthma, according to an updated review of studies. Moreover, such programs could lead to fewer hospitalizations for children.
Columbia University Science & Technology Ventures (STV) and New York-based EndoRobotics, Inc. have entered into an exclusive license agreement to develop and commercialize a micro-robotic imaging and surgical device platform designed to reduce the complexity of minimally invasive surgical (MIS) procedures and improve patient outcomes.
The Novartis investigational bronchodilator QAB149 (indacaterol) met the primary efficacy endpoints of improved lung function compared to placebo at 12 weeks in three pivotal phase III studies in chronic obstructive pulmonary disease (COPD) patients. In secondary endpoints of these studies, QAB149 demonstrated clinically relevant lung function improvements within five minutes of the first dose, lasting for 24 hours in COPD patients.
Physicians can now provide potentially safer and more accurate diagnostic procedures with the first and only high-definition endoscopic ultrasound (EUS) needle technology. Cook Medical, the only full-line supplier of endoscopic medical devices, has designed a complete line of high-definition EUS biopsy needles that are up to three-times brighter than others on the market. With the addition of the 19 and 25 gage EchoTip® Ultra with High Definition Fine Needle Aspiration (HDFNA™) needles, the EchoTip Ultra HDFNA represents the next level of precision in EUS, an essential diagnostic tool that yields more accurate images of the gastrointestinal (GI) tract than traditional ultrasound and provides minimally invasive access to areas that are traditionally difficult to reach.
Cancer patients treated with the widely used drug bevacizumab in combination with chemotherapy are at significantly greater risk of potentially life-threatening gastrointestinal (GI) perforations (a hole in the wall of the stomach, small intestine or large bowel)-particularly patients with advanced colorectal cancer and renal cell cancer, according to an Article published Online First and in the June edition of The Lancet Oncology.
Tackling the very causes of ageing, rather than treating the symptoms in a piecemeal way offers the best prospects for dealing with the diseases and effects of ageing according to a public lecture being given at the Royal Society tonight.
Rep. Frank Wolf (R-Va.) on Friday in a letter to President Obama said that the U.S. could lose its triple-A bond rating if Congress does not act quickly to overhaul U.S. entitlement programs, including Medicare and Medicaid, and reduce federal debt, the AP/Detroit News reports.Several lawmakers in Congress over the past two years have introduced bills to create a bipartisan task force to address the growing costs and potential insolvency of entitlement programs, such as Medicare and Medicaid. Wolf is a co-author of one such bill (HR 1557). A federal report issued earlier this month found that the trust fund Medicare uses to pay for beneficiaries" hospital care will be insolvent by 2017, two years earlier than previously predicted.According to the legislation, the task force would be responsible for developing a "grand bargain" package of recommendations to Congress on tax increases and benefits related to the entitlement programs. However, the task force has been opposed by House Speaker Nancy Pelosi (D-Calif.), several top congressional committee leaders and White House aides who said that other priorities, such as a health care system overhaul, need to be addressed first.Wolf said, "The fact that the leadership has been opposed to it has been a problem," adding, "There"s an economic tsunami off the coast and it"s ready to wipe us out." David Walker, president of the Peter G. Peterson Foundation, said that currently the potential for the task force is not good but that it should improve as the economy recovers and Congress can offer more attention to the plan (Raum, AP/Detroit News, 5/24). Opinion Pieces
The New Jersey Senate on Thursday unanimously passed legislation (A 2030) that would require pharmacists to inform consumers when they have substituted generic drugs for brand-name prescriptions, the Newark Star-Ledger reports. The General Assembly approved the legislation in February and it now moves to Gov. Jon Corzine (D).If Corzine signs the bill, the law would take effect within 180 days, making New Jersey the first state in the U.S. to have such a requirement. State Sen. Christopher Bateman (R) said, "We"re hoping that other states will follow our lead" (Megerian, Newark Star-Ledger, 5/22).
"The FDA as a Public Health Agency," New England Journal of Medicine: In the perspective, FDA Commissioner Margaret Hamburg and Joshua Sharfstein, principal deputy commissioner of the agency, provide "a broad overview" of how they plan to "embrace" the agency"s mission to protect the public"s health. Hamburg and Sharfstein discuss their plans to work with other U.S. agencies, such as NIH, CDC and CMS, as well as challenges posed by globalization. In addition, they write that they will work to improve transparency at FDA (Hamburg/Sharfstein, NEJM, 5/26).
In recognition of Stroke Awareness Month in May, a national stroke coalition announced that its member organizations have adopted a new public education message: "Stroke strikes fast. You should too. Call 9-1-1." The Brain Attack Coalition (BAC), chaired by the National Institute of Neurological Disorders and Stroke (NINDS) and composed of leading organizations committed to stroke prevention and treatment, recognized the need for a new actionable message that all member organizations can use with their current stroke awareness efforts. The NINDS is part of the National Institutes of Health.
Despite reports indicating that placement of retail clinics are determined by physician shortages and higher uninsured populations, these clinics appear to be located in more advantaged neighborhoods, according to a report in the May 25 issue of Archives of Internal Medicine, one of the JAMA/Archives journals.
Available evidence supports the use of online or other computer-based smoking cessation programs for helping adults quit smoking, according to a meta-analysis of previously published studies appearing in the May 25 issue of Archives of Internal Medicine, one of the JAMA/Archives journals.
Heart rate and core temperature spike for NASCAR pit crew athletes during pit stops, a combination of physiological demands that may take a toll on crew performance, says a study presented today at the American College of Sports Medicine (ACSM) 56th Annual Meeting in Seattle. These factors, linked with demand for highly skilled pit crews, heighten the need for physical conditioning of pit crew athletes based on the unique demands of the sport.
Could a holiday in the sun reduce the risk of developing multiple sclerosis? In a recent review for F1000 Medicine Reports, Bridget Bagert and Dennis Bourdette highlight recent advances in potential treatments.
Researchers at Iowa State University have found that increased expression of a form of cytochrome P-450 (CYP4B1) is a key marker of inhibition of colitis in mice by caffeic acid, an anti-inflammatory antioxidant compound widely distributed in foods. The results, which appear in the June 2009 issue of Experimental Biology and Medicine, implicate CYP4B1, a form of cytochrome P450 previously found to be associated with resolution of allergic inflammation in another model. The normalization of CYP4B1 by caffeic acid treatment was associated with significant lessening of colitic damage, assessed by examining colon histopathology. In comparison with rutin, an anti-inflammatory flavonoid and hypoxoside extract, a botanical known as African potato previously shown to protect against colitis, all three compounds had anti-inflammatory effects, suppressing myeloperoxidase, IL-17 and iNOS and increasing IL-4, known factors associated with inflammation responses. But only caffeic acid protected against the dextran sulfate sodium induced colitis. Its novel mechanism related to CYP4B1 is being studied further. The research team, Zhong Ye, a graduate student in Toxicology, along with Microbiology graduate students Zhiping Liu and Abigail Henderson, Visiting Scientist Kwangwon Lee, Korea University, Dr. Michael Wannemuehler, Veterinary Microbiology, Dr. Jesse Hostetter, a veterinary pathologist, and Dr. Suzanne Hendrich, Toxicologist and Nutritionist, performed studies in 8 week old mice fed the various dietary components and then exposed to dextran sulfate sodium in a mildly irritating dose to induce colitis. Dr. Hendrich noted that "this study of caffeic acid will help us to advance studies of botanicals and plant foods with respect to their ability and mechanisms of inhibiting colitis, and perhaps colon cancer, because colitis increases risk for this disease".
A new way of assessing professionalism among medical students could help to make better doctors, a new research study suggests.
High-grade prostatic intraepithelial neoplasia (HGPIN) carries a high predictive value for future diagnosis of prostate cancer. Research published in the open access journal BMC Urology has shown that 41.8% of patients whose extended core biopsy led to an initial diagnosis of HGPIN were subsequently diagnosed with prostate cancer.
Mice and rabbits immunized with a multimeric-L2 protein vaccine had robust antibody responses and were protected from infection when exposed to human papillomavirus (HPV) type 16 four months after vaccination, according to a new study published in the May 26 online issue of the Journal of the National Cancer Institute.
ONCOLOGY: Targeting the more lethal form of the cancer rhabdomyosarcoma
Antiabortion-rights "protesters intend to turn Notre Dame"s commencement into a circus" because of their opposition to the university"s invitation to President Obama to receive an honorary degree and deliver a speech at the ceremony on Sunday, Philadelphia Inquirer columnist Monica Yant Kinney writes in an opinion piece. "Never mind that a majority of Catholics voted for Obama in 2008, approve of his job performance and support the university"s invitation," she says. Yant Kinney, a Notre Dame alumna, notes that the university has been inviting presidents to its campus since former President Eisenhower was in office. "Most recently, the class of 2001 honored George W. Bush, who as governor of Texas presided over scores of executions," she writes, adding, "The Catholic Church vehemently opposes the death penalty, yet no bishops boycotted Bush"s visit."Yant Kinney continues that antiabortion-rights advocates Randall Terry, Alan Keyes and others "have already been arrested in the last two weeks," and "[s]ome demonstrators pushed strollers with baby dolls dripping in fake blood." She asks, "And what to make of the soul who hired an airplane to pull a banner of an aborted fetus right by the statue of the Virgin Mary? Where"s the reverence for life in that gesture?" Yant Kinney concludes, "The anti-Obama protesters may be trying to change his mind, but as for hope? With such crass tactics, they"re mostly hoping for attention. I guess they succeeded" (Yant Kinney, Philadelphia Inquirer, 5/13).
Statins, a commonly prescribed class of drugs used by millions worldwide to effectively lower blood cholesterol levels, may actually have a negative impact in Multiple Sclerosis (MS) patients treated with high daily dosages.
The International Coordinating Group (ICG) on Yellow Fever Vaccine Provision is warning that the global emergency stockpile of yellow fever vaccine for the world"s most vulnerable populations in Africa is under threat.
Boston Scientific Corporation (NYSE: BSX) announced it has received approval from the U.S. Food and Drug Administration (FDA) to market its TAXUS(R) Liberte(R) Atom(TM) Paclitaxel-Eluting Coronary Stent System, a highly deliverable, next-generation drug-eluting stent (DES) specifically designed for treating small coronary vessels. It was approved for use in vessels as small as 2.25 mm in diameter and joins the TAXUS(R) Express(R) Atom(TM) Stent as the only drug-eluting stents approved for small vessel use in the U.S. The Company plans to begin a full U.S. launch of TAXUS Liberte Atom next month.
Pneumonia is an infection of the lungs that is caused by bacteria, viruses, fungi, or parasites. It is characterized primarily by inflammation of the alveoli in the lungs or by alveoli that are filled with fluid (alveoli are microscopic sacs in the lungs that absorb oxygen). At times a very serious condition, pneumonia can make a person very sick or even cause death. Although the disease can occur in young and healthy people, it is most dangerous for older adults, babies, and people with other diseases or impaired immune systems.
Medical students and teaching staff have welcomed the Review & Modernisation of Supplement for Undergraduate Medical and Dental Education (SUMDE) consultation, which was undertaken by the DHSSPS.
Interactive Medica, the leading Pharma SaaS provider, today launches IM Strategic Selling, a new Software as a Service (SaaS) solution that enables promotional teams, managers and executives to identify, collaborate, plan and manage goals, strategies and activities for current and potential Key Accounts.
Two newspapers recently published opinion pieces on abortion-related public opinion polls. Summaries appear below.~ Steven Kull, Baltimore Sun: Although "many Americans feel morally conflicted about" abortion, it is a "common error to believe that the American electorate is deeply divided about how the government should deal with" the procedure, Kull -- director of WorldPublicOpinion.org and the Program on International Policy Attitudes at the University of Maryland -- writes in a Sun opinion piece. He adds that "there is substantial consensus that the government should not criminalize abortion." According to Kull, a new CNN poll found that 68% of respondents believe Roe v. Wade should not be overturned, and a recent WorldPublicOpinion.org poll found that when asked, "Do you think the government should be involved in trying to discourage abortion or do you think the government should leave these matters to the individual," 69% said that the matter should be left to the individual. Kull adds that "of the 29% who said that the government should be involved in trying to discourage abortions, a remarkably low 8% favored using criminal enforcement methods." According to Kull, other polls have found if "given a middle option -- somewhere between strict prohibition and government permission -- a significant number will choose it." Kull writes that "once the moral question is differentiated from the question of how the government should act, it does appear that there is substantial consensus that abortion should not be criminalized." He concludes, "Once the option of criminal enforcement is taken off the table, constructive options are more likely to emerge and can be an effective focus for the energies freed up from the incessant debates about abortion" (Kull, Baltimore Sun, 5/22).~ Cheryl Wetzstein, Washington Times: "It"s rather ironic that as the most pro-choice government in U.S. history settles into its seats," a Gallup poll "finds that most Americans are pro-life," columnist Wetzstein writes in a Times opinion piece. She adds, "Some observers have tried to pooh-pooh this result, but it doesn"t surprise me for two reasons." Wetzstein writes that her "experience with youth, both personally and professionally, is that they often recoil at abortion," adding, "So I find a pro-life trend in youth to be quite plausible." She continues, "Second, I think some aging baby boomers are changing their views," adding, "People generally become more conservative and self-reflective with age. Legacies matter. Hindsight is 20/20. Regrets appear." Wetzstein concludes, "My suspicion is that in more than a few cases, baby boomers who were willing to have abortions are not at ease with the idea of losing their grandchildren," adding, "It may be that in the autumn of life, being "pro-life" has a whole new meaning" (Wetzstein, Washington Times, 5/26).
Australian healthcare company Stirling Products Limited (ASX:STI) is pleased to announce another milestone in the expansion of the licensed (pending joint venture approval) botanical products to markets outside of Ukraine. Immunoxel (Dzherelo) has been granted approval in South Africa. This approval will allow immediate sales of the phytoconcentrate as an immune adjuvant for TB and HIV treatment.
Providing mass drug administration of praziquantel, at a cost of 32 cents per child, to school-aged children to prevent female genital schistosomiasis could also reduce and possibly interrupt HIV/AIDS transmission throughout many rural areas of sub-Saharan Africa, according to a new analysis published in the open-access journal PLoS Neglected Tropical Diseases.
Black women are nearly three times as likely as white women to have a vitamin D deficiency, which is linked with an increased risk of the vaginal infection bacterial vaginosis, according to a study published in the June issue of the Journal of Nutrition, the New York Times reports. Black women likely have lower levels of vitamin D because the higher amount of pigment in their skin prevents the body from absorbing the vitamin.For the study, researchers led by Lisa Bodnar, an assistant professor of epidemiology at the University of Pittsburgh, examined 209 white pregnant women and 260 black pregnant women at a Pittsburgh clinic. More than half of the women had low levels of vitamin D, the study found. Women whose vitamin D levels were 50 nanomoles or less had a 26% increased risk of BV, while women whose vitamin levels were less than 20 nanomoles had a 65% increased risk of the infection. About 52% of black women had the infection, compared with 27% of white women, the study found (Bakalar, New York Times, 5/26). The study found that 93% of women with BV had low vitamin D levels and that BV prevalence decreased as vitamin levels increased.In addition, although black women were more likely to have BV, white women who had low levels of vitamin D were as likely to have the infection as black women. Poor diets and obesity also contributed to a vitamin deficiency. Bodnar noted that black women are less likely than white women to meet dietary recommendations for vitamin D. Bodnar recommended that women discuss their level of vitamin D with their physicians and that pregnant women take a prenatal vitamin, which typically includes vitamin D.According to the Pittsburgh Post-Gazette, Bodnar"s research team has received NIH funding to conduct a study of whether vitamin D deficiency in women increases the risk of poor birth outcomes and whether high infant mortality among blacks can be attributed to factors such as obesity (Templeton, Pittsburgh Post-Gazette, 5/23).
The physical challenges and demands of participating in competitive high school marching band are similar to those experienced by athletes who compete in sports, according to a study presented at the American College of Sports Medicine"s 56th Annual Meeting in Seattle.
Z-Cube Srl, the corporate venture arm of Zambon Company SpA, and Yissum Research Development Company Ltd., the technology transfer company of the Hebrew University of Jerusalem, announced today that they have entered into a license agreement for Z-Cube to develop and commercialize an innovative nanotechnology drug delivery system for the treatment of pain. The technology was invented by Professor Elka Touitou from the Department of Pharmaceutics, Faculty of Medicine, at the Hebrew University of Jerusalem.
The Lung Association congratulates Health Minister Leona Aglukkaq and the Government of Canada on its announcement of imminent changes to the federal Tobacco Act that include:
ImmunoVaccine Technologies Inc. (IVT), a Canadian vaccine development
Senate Democrats on Wednesday worked with senior White House adviser David Axelrod to craft a health care message focused on affordability and choice, the AP/Contra Costa Times reports (Werner, AP/Contra Costa Times, 5/13). The meeting followed the release of a memo last week by Republican strategist Frank Luntz outlining how to criticize Democratic plans for health reform (Budoff Brown/McGrane, Politico, 5/13). Senate Majority Whip Richard Durbin (D-Ill.) said Luntz"s memo was "an interesting catalyst for us" (AP/Contra Costa Times, 5/13).Axelrod presented Democrats with polling data about what U.S. residents are seeking from a health care overhaul and discussed better word choices, such as "shared responsibility" rather than "mandates" for coverage requirements. According to CongressDaily, the meeting centered Democrats on a coordinated message that the U.S. health care system must be affordable and accessible and should be patient-focused (Edney/Condon, CongressDaily, 5/13). Sen. Evan Bayh (D-Ind.) said that many Democrats felt "unease that we did not have a strategy" to answer the attacks coming from Republicans (Pear, New York Times, 5/14). Senate Finance Committee Chair Max Baucus (D-Mont.) said, "Everybody in the room had been a little nervous that, "Gee, Democrats don"t have their act together"" (CongressDaily, 5/13). However, Bayh said that "Axelrod came to reassure us that they do have a strategy" (New York Times, 5/14). Durbin said, "This is an effort to coordinate our message so we present a health care reform effort the American people trust" (Armstrong, CQ Today, 5/13). According to Durbin, Axelrod emphasized that Democrats should continue with the campaign theme that the goal of an overhaul is to "fix what"s broken in the system and preserve what"s good" (Young, The Hill, 5/13).Sen. Charles Schumer (D-N.Y.) said, "We believe the public shares our views. But we don"t want to be overwhelmed by either res, messaging or boots on the ground." He added, "We won"t make the mistake of 1993-94." According to the New York Times, a plan developed by the administration of former President Clinton "collapsed" in the face of Republican criticism (New York Times, 5/14).
Scientists at the Medical Research Council Laboratory of Molecular Biology uncover how an important cancer gene, BRCA1, works by increasing the accuracy with which broken DNA is repaired. Women who inherit a faulty version of the BRCA1 gene are at a higher risk of developing breast or ovarian cancer.
The most reliable method of diagnosing gout is to aspirate the joint in order to obtain fluid to verify the presence of monosodium urate crystals (uric acid). Up to now, computed tomography (CT) has played a limited role in the evaluation of gout, since conventional CT systems cannot reliably verify deposits of uric acid. However, a current study at the Vancouver General Hospital in Canada gives rise to speculation that dual-energy computed tomography (DECT) could radically change the diagnosis of this disease. DECT enables fast, noninvasive examinations and, based on initial evaluations, has the potential to surpass the invasive gold standard and clinical examination in terms of reliability. Investigations have confirmed the high sensitivity of the DECT method in detecting uric acid deposits. The Canadian scientists used the SOMATOM Definition computed tomography (CT scanner) from Siemens for their investigation. This system is the only CT scanner worldwide that features two X-ray tubes capable of simultaneously producing different energies.