Oncology
The Associated Press reports that "the Indian Health Service is continuing to lose equipment at an alarming rate despite efforts to better account for the agency"s property, according to congressional investigators. In a report issued Wednesday, the Government Accountability Office said the government agency lost about 1,400 items worth $3.5 million between October 2007 and January 2009 - including $37,000 in lab equipment at a Navajo health care facility and a $7,300 trailer in Nashville, Tenn. Those losses came after an estimated $15.8 million in equipment was unaccounted for between the 2004 and 2007 budget years. Those losses were reported by the GAO in June 2008, when investigators also charged that the Indian Health Service had falsified documents to cover up some of the missing property."
"Even with the Medicare drug benefit, even with the prevalence of low-cost generics, even with loss-leader discounting by big chains, many Americans still find themselves unable to afford the prescription medications that manage their life-threatening conditions," The New York Times reports. In some areas, "the recession has heightened the struggle. National surveys consistently find that as many as a third of respondents say they are not complying with prescriptions because of cost, up from about a fourth three years ago."
A combination of measures taken to improve nutrition, indoor air pollution, immunization and child pneumonia case management could reduce total child mortality worldwide by 17 percent and global pneumonia deaths by more than 90 percent, according to a study published in the June issue of the Bulletin of the World Health Organization, UPI reports.
Health advocates at a civil society meeting in Nairobi, Kenya, called for African governments to improve access to basic health care, IRIN reports. "African governments are failing to offer even the most basic healthcare that could save lives, speakers warned," writes IRIN.
More than 80 community pharmacists from the National Community Pharmacists Association (NCPA) and several patients met with the Federal Trade Commission (FTC) today to discuss the negative impact of the March 2007 CVS/Caremark merger and to urge the FTC to re-examine it.
Many children who are retained in kindergarten, first or third grade for academic reasons do not subsequently receive a document outlining the individualized special education services they should receive, according to a report in the June issue of Archives of Pediatrics & Adolescent Medicine, one of the JAMA/Archives journals.
EpiCept Corporation (Nasdaq and OMX Nordic Exchange: EPCT) has released new long-term data showing that the use of Ceplene® when administered in conjunction with low-dose interleukin-2 (IL-2) provides durable protection from leukemia relapse in patients with Acute Myeloid Leukemia (AML), based on a minimum of six years of follow-up. These data will be presented on June 6, 2009 at the European Hematology Association"s (EHA) 14th Congress in Berlin, Germany.
"With a continuously ageing population the incidence of osteoporosis is steadily rising. This does not only pose problems to the individuals concerned but is also an enormous challenge for our societies" according to Professor Wolfhart Puhl, past president of the European Federation of National Associations of Orthopaedics and Traumatology (EFORT). Prof. Puhl, of the Orthopç¤dikum Allgç¤u, Germany, who is in Vienna for the EFORT Congress, emphasized that the problem"s "dimension is frequently underestimated. Policy makers and funding agencies do not always consider this development sufficiently in their planning."
Scientists and engineers at UC Santa Barbara and other researchers have developed a nanoparticle that can attack plaque - a major cause of cardiovascular disease. The new development is described in a recent issue of the Proceedings of the National Academy of Sciences.
A recent surge in immigration rates has led psychologists to study how these families are coping and thriving in their adopted countries. In a special June issue of the Journal of Family Psychology, published by the American Psychological Association, researchers report that close family ties are crucial for immigrants" successful transition to their new country.
Nearly 1,000 researchers, clinicians and mental health advocates are expected to attend the Eighth International Conference on Bipolar Disorder, June 25 to 27, at the David L. Lawrence Convention Center in Pittsburgh. The event is held only once every two years and is the largest meeting of its kind solely devoted to bipolar disorder, a disease that affects almost six million Americans.
Bipolar disorder is misdiagnosed as depression in over a quarter of cases, a new study suggests. The research is presented today at the Royal College of Psychiatrists" 2009 Annual Meeting in Liverpool.
Commenting on a new report on the use of management consultants by the NHS and the Department of Health, published by the Health Select Committee, Dr Peter Carter, Chief Executive & General Secretary of the Royal College of Nursing (RCN), said:
A pioneering study of certified nursing assistants (CNAs) in nursing homes reveals that more than half of them incurred at least one work-related injury in the previous year. One in three received some kind of means-tested public assistance, and nearly half of those without medical insurance claimed they could not afford their employer-sponsored plan.
The Alabama Department of Public Health has confirmed its first novel H1N1 influenza case in
A new breakthrough in adult stem cell technology has three Texarkana neurosurgeons leading their industry by utilizing concentrated stem cells for spine surgery. The innovative technique is improving the desired results of surgical interventions for back pain. Leading researchers in the orthopedic and spine industry are predicting the latest developments in this field of medicine will become mainstream practice and, potentially, a standard of care for surgical treatments of severe back pain.
Palomar Medical Technologies Inc. (Nasdaq: PMTI), a leading researcher and developer of light-based systems for cosmetic treatments, announced that it has become the first company to receive a 510(k) over-the-counter (OTC) clearance from the United States Food and Drug Administration (FDA) for a new, patented, home use, laser device for the treatment of periorbital wrinkles. OTC clearance allows the device to be marketed and sold directly to consumers without a prescription.
CEL-SCI Corporation (NYSE AMEX: CVM) announced that its collaborators at the University of Hawaii reported on data at the annual American Society for Microbiology in Philadelphia, PA. This data demonstrates that vaccines utilizing its L.E.A.P.S.(TM) (Ligand Epitope Antigen Presentation System) vaccine technology with specificity for particular Mycobacterium tuberculosis (TB) antigens can elicit immune responses that would be protective against tuberculosis and have the potential to treat swine and other H1N1 influenzas.
The Extremadura Regional Government of Spain and IBM (NYSE: IBM) have launched an electronic prescription system in 680 pharmacies in Extremadura, where health centres and pharmacies are now computerised and able to prescribe and dispense prescription medications electronically.
In recent decades, there have been periodic reports of a worldwide decline in sperm count and quality. Male infertility has ostensibly been on the rise, accompanied by increases in testicular cancer and hypospadias -- a congenital defect in which the opening of the urethra is on the underside, rather than at the end, of the penis. Taken together, these three conditions have been termed testicular dysgenesis syndrome.
The axon is a part of the neuron through which nerve impulses are transmitted, and at the end of which is located the synapse, which connects it to another neuron. In the event of a lesion, the axon is the component which must be regenerated in order to restore the connections between the different neurons and re-form the nerve.
UroToday.com - Together with Drs. Heruti, Bechor, Justo and Galor, we studied 815 Israeli male adults of whom 305 had complete data and were included in the statistical analysis. In the analyzed population, 2.1% of people without erectile dysfunction (ED) had advanced periodontal disease (defined as recession of periodontal bone of 6 mm or more) in comparison to 9.8% of the mild ED and 15.8% of the moderate/severe ED populations, respectively. However, due to the relatively small groups, we could not present the odds ratio. We are now planning a large-scale study to further establish the association between the two conditions.
Everyone knows that smoking can kill you, but did you know that it may help with your allergies? A new study shows that cigarette smoke can prevent allergies by decreasing the reaction of immune cells to allergens.
Eleven people were charged in an indictment unsealed on Thursday with "scamming Medicare to get painkillers," the Associated Press reports. "A federal indictment in Detroit says the government unwittingly paid more than $480,000 to a phony health-care business that was a front for acquiring and selling painkillers." Authorities say Quick Response Medical Professionals paid people up to $220 to be seen by a doctor and that those visits were then reimbursed by Medicare. The case also involves thousands of doses of OxyContin worth more than $5 million that were sold during 2007 and 2008. The AP noted that "the government says Medicare and Medicaid fraud costs taxpayers billions each year" (6/4).
To reduce an estimated half million deaths and two million hospitalizations from diarrhea caused by rotavirus each year, the WHO on Friday recommended that oral rotavirus vaccines be added to national childhood immunization programs, broadening access to the vaccine in the developing world,
On the 16th May Member of European
Dialysis is the artificial process of getting rid of waste (diffusion) and unwanted water (ultrafiltration) from the blood. This process is naturally done by our kidneys. Some people, however, may have failed or damaged kidneys which cannot carry out the function properly - they may need dialysis. In other words, dialysis is the artificial replacement for lost kidney function (renal replacement therapy). Dialysis may be used for people who have become ill and have acute kidney failure (temporary loss of kidney function), or for fairly stable patients who have permanently lost kidney function (stage 5 chronic kidney disease).
The following are based on abstracts or posters to be presented at the annual meeting of the American Society of Clinical Oncology (ASCO) in Orlando, Florida, May 29 - June 2, 2008.
Paramedic, Mr Jonathan Knight has been struck off the HPC Register after he
Vanderbilt-Ingram Cancer Center researchers have uncovered a gene signature that may help predict clinical outcomes in certain types of breast cancer.
The first licensed vaccine in Europe to protect British travellers against a potentially fatal mosquito disease is being launched today.
Somaxon Pharmaceuticals, Inc. (Nasdaq: SOMX), a specialty pharmaceutical company focused on the in-licensing, development and commercialization of proprietary branded pharmaceutical products and late-stage product candidates for the treatment of diseases and disorders in the central nervous system therapeutic area, today announced that it has resubmitted its New Drug Application (NDA) to the U.S. Food and Drug Administration (FDA) for Silenor® (doxepin) for the treatment of insomnia.
Recent calls by California Gov. Arnold Schwarzenegger and others to study the legalization of marijuana as a way of boosting tax revenues are "irresponsible" and send a dangerous message, the chairman of the board of the drug abuse education program D.A.R.E., prominent Los Angeles attorney Louis "Skip" Miller, said today. "Marijuana is a dangerous drug with numerous demonstrable ill effects on health," Mr. Miller added.
Aspyra, Inc. (AMEX: APY) announced plans to demonstrate the latest release of AccessRAD, their RIS/PACS product at the upcoming Radiology Business Management Association (RBMA) 2009 Radiology Summit held at Lowes Royal Pacific Resort in Orlando, FL, June 7 - 10, 2009, Booth 411.
Lantheus Medical Imaging, Inc., a worldwide leader in diagnostic imaging, announced today that the company"s leading imaging agent, Cardiolite® (Kit for the Preparation of Technetium Tc99m Sestamibi for Injection), was used in a recently completed five-year study examining appropriate treatment regimens for patients with type 2 diabetes and coronary artery disease. The results of this study, known as The Bypass Angioplasty Revascularization Investigation 2 Diabetes (BARI 2D), will be presented by the University of Pittsburgh Graduate School of Public Health at a special symposium on Sunday, June 7, 2009, from 4:15 p.m. - 5:15 p.m. (CT) at the American Diabetes Association 69th Scientific Sessions in New Orleans.
Staff at Scotland"s care watchdog have been praised for completing a specialist course aimed at improving care standards across the country.
New treatments to ease or even cure the most common cancer affecting Australian men are a step closer to reality with a $1.25 million grant awarded to QUT prostate cancer researcher Professor Colleen Nelson today.
Patients with symptoms of stroke or transient ischemic attack (TIA or brain attack) are missing out on potentially life saving treatment because they are routinely considered by the NHS as low priority cases. Instead of being fast-tracked into hospital for surgery the vast majority of patients are spending weeks and sometimes months on poorly managed referral pathways with the risk of going on to have more severe strokes.
Checking lymph nodes during surgery and assessing the hormone status of tumours could help improve breast cancer survival in the UK, according to research published today in Annals of Oncology.
The Lupus Foundation of America (LFA) convened an Expert Panel June 1-2 to address the urgent and unmet need for the development and approval of new, safe, effective, and tolerable medications for people with lupus. It has been more than 50 years since the U.S. Food and Drug Administration (FDA) approved a new drug specifically to treat lupus. Discussions during the two-day meeting in Washington, DC focused on how to better conduct studies of potential new lupus treatments, including clinical endpoints, diagnostic tools, background medications, and clinical trial design.
The long-awaited results of the Bypass Angioplasty Revascularization Investigation in Type 2 Diabetes (BARI 2D) study, a multicenter trial led by the University of Pittsburgh Graduate School of Public Health, were reported at a symposium here today at the American Diabetes Association"s 69th Scientific Sessions.
Results of the long-awaited Rosiglitazone Evaluated for Cardiac Outcomes and Regulation of Glycaemia in Diabetes (RECORD) study were presented here in a symposium at the American Diabetes Association"s 69th Scientific Sessions. The results are being simultaneously published online in The Lancet.
Although they have no symptoms themselves, the mayor of New Orleans, Louisiana, USA, Ray Nagin, his wife and a member of his security staff
UC Santa Barbara and Sansum Diabetes Research Institute scientists have demonstrated for the first time that an automated artificial pancreas system (APS) can safely and effectively maintain desired blood glucose levels in patients with type 1 diabetes. The clinical study results will be presented today in a late-breaking poster session(1) at the American Diabetes Association"s 69th Scientific Sessions in New Orleans.
A study in the June issue of Clinical Gastroenterology and Hepatology, published by Elsevier, demonstrates that the Hepascore(TM) liver fibrosis blood-serum test panel may help physicians more accurately diagnose and stage liver fibrosis in patients with chronic hepatitis C (HCV), potentially alleviating the need for liver biopsy, the standard of care for staging fibrosis, in a particular subset of patients. The Hepascore test panel is provided exclusively by Quest Diagnostics Incorporated (NYSE: DGX), the world"s leading provider of diagnostic testing, information and services.
Swedish global industrial group, Sandvik, is announcing the development of the new Sandvik European Center of Excellence (SECoE) for finish processing and supply management activities for orthopedic implants and instruments.
At a June 12 forum cosponsored by Health
The Washington Independent examines a recent Government Accountability Office (GAO) report, which found that a federal law requiring most international food aid to come from U.S. farmers could be "hobbling efforts to feed the world"s hungry." Currently, Food for Peace - the nation"s largest food aid program - "requires that the crops be purchased from U.S. growers, processed through U.S. companies, and shipped using U.S.-flagged vessels," according to the article.
South African President Jacob Zuma on Wednesday said he wants to have 80 percent of HIV-positive South Africans who need antiretrovirals (ARVs) on them by 2011, BuaNews reports (BuaNews/allAfrica.com, 6/3). The announcement was part of Zuma"s first state-of-the-nation address, when he discussed ways the government would strive to "step up measures to improve health care in Africa"s strongest economy," Reuters writes. "We have set ourselves the goals of reducing inequalities in health care ... and step up the fight against the scourge of HIV and AIDS, TB and other diseases," Zuma said (Roelf, Reuters, 6/4).
Economists say taxing health benefits not only could raise billions per year for health care reform efforts, but also could make the system run better, NPR and KHN report.
Democrats working feverishly on health care reform "face increasingly noisy protests from those on the left who complain that a national program like those in Europe has been excluded from the debate," The Washington Post reports.
DrugScope has welcomed the National Treatment Agency for Substance Misuse"s announcement of an extra ÷£11.8m government investment in drug treatment.
Clinical investigators observed that Soliris® (eculizumab), a first-in-class terminal complement inhibitor developed by Alexion Pharmaceuticals, Inc. (Nasdaq: ALXN), reduced hemolysis (red blood cell destruction) and improved symptoms in nine patients with paroxysmal nocturnal hemoglobinuria (PNH) who had received no blood transfusions prior to initiating Soliris therapy.
AdvanDx announced it received FDA 510(k) clearance for GBS PNA FISH(R) for detection of Streptococcus agalactiae, aka Group B Strep, from turbid Lim Broths inoculated with vaginal and rectal swabs obtained from pregnant women between 35 and 37 weeks gestation. The 90 minute molecular diagnostic test enables rapid and highly sensitive detection of Group B Strep from Lim Broths to help detect colonization in pregnant women.
Primary care pediatricians may be under-diagnosing sleep disorders in children and teens, according to a research abstract presented on June 8 at SLEEP 2009, the 23rd Annual Meeting of the Associated Professional Sleep Societies.
In recognition of World Blood Donor Day on June 14th, the National Anemia Action Council (NAAC) is providing the online tutorial Anemia & Blood Donation to blood donors who have been deferred because of a low blood count.
According to a research abstract presented on June 8, at SLEEP 2009, the 23rd Annual Meeting of the Associated Professional Sleep Societies, active problem solving strategies are associated with successful use of continuous positive airway pressure (CPAP) therapy for the treatment of obstructive sleep apnea (OSA).
Men with insomnia and sleep duration of six or fewer hours of nightly sleep are at an increased risk for mortality, according to a research abstract presented on June 8, at SLEEP 2009, the 23rd Annual Meeting of the Associated Professional Sleep Societies
Alzheimer"s disease and its precursor, mild cognitive impairment, appear to be associated with an increased risk of death among both white and African American older adults according to a new, long-term research study by neurological experts at the Alzheimer"s Disease Center at Rush University Medical Center. The study findings are published in the June issue of Archives of Neurology, one of the JAMA/Archives journals.
Scientists at South Dakota State University are exploring the mechanisms by which a substance derived ultimately from Red Sea coral could help treat skin cancer.
New research from the University of Virginia Health System shows that, when combined, two emerging medical technologies hold significant promise for treating the most deadly and devastating form of brain tumor, glioblastoma multiforme (GBM).
Low income, conflict-affected countries such as Afghanistan, Sudan and
A new lung cancer therapy employing a vaporized viral vector to deliver a cancer-inhibiting molecule directly to lung tissue shows early promise in mouse trials, according to researchers at the Ministry of Education, Science and Technology in Korea.
A provocative debate in this week"s PLoS Medicine examines whether it
The UK"s longest established meningitis charity - the Meningitis Trust - is encouraging carers across the UK to speak out and earn the recognition that they deserve, as part of Carer"s Week (June 8 - 14).
Gregg Duester, Ph.D., professor of developmental biology at Burnham Institute for Medical Research (Burnham), along with Xianling Zhao, Ph.D., and colleagues, have clarified the role that retinoic acid plays in limb development. The study showed that retinoic acid controls the development (or budding) of forelimbs, but not hindlimbs, and that retinoic acid is not responsible for patterning (or differentiation of the parts) of limbs. This research corrects longstanding misconceptions about limb development and provides new insights into congenital limb defects. The study was published online in the journal Current Biology on May 21.
A majority of Southwesterners - 86 percent - think the U.S. health care system is in need of some reform, and more than half - 53 percent - indicate "a great deal of reform" is needed, according to the most recent Arizona State University-Southwest Poll.
"The new swine influenza virus [H1N1], which appeared suddenly after years of warning about a potential pandemic of avian influenza, upset the WHO"s assumptions that most people have the same understanding of the word pandemic," says the New York Times in a report that examines the difficultly health experts have had when attempting to agree upon what constitutes a pandemic.
On June 17 from 6.30pm to 8.30pm, Terrence Higgins Trust is launching a new Positive Self Management Programme for gay men living with HIV. The free workshops in Ladbroke Grove, London will run at the same time every subsequent Tuesday for seven weeks.
President Obama"s carefully worded health care reform letter to key Senate Democrats last week highlighted the growing role the president is taking in overhaul efforts, Politico reports.
In the White House"s pitches for health care reform, controlling costs has replaced universal coverage as the leading imperative to overhaul the system. A top White House economist, Christina Romer, said in a public appearance Monday, "Good health care reform is good economic policy," the San Francisco Chronicle reports. "Fixing what"s wrong with our health care system is no longer a luxury we hope to achieve - it"s a necessity we cannot postpone any longer" (Abate, 6/9).
Congressional Democrats seeking leadership are feeling Sen. Edward Kennedy"s absence in the looming health care reform debate as he continues his battle with brain cancer, and struggles to return to Washington, The New York Times reports.
A New York City law that will go into effect in July could make it easier for antiabortion-rights protesters to be arrested for restricting access to abortion clinics or harassing people trying to enter the facilities, the New York Times reports. Current law allows authorities to make arrests only if the person directly affected, such as a woman entering a clinic, is willing to press charges. However, the new law would allow third parties, such as clinic workers, to press charges if they witnessed the activity, the Times reports. New York City"s Dr. Emily"s Women"s Health Center and NARAL Pro-Choice New York spearheaded efforts to pass the legislation in response to antiabortion-rights demonstrators who target women on their way to clinics and attempt to persuade them to carry their pregnancies to term. Clinic workers report that the protesters also have harassed women as they left the subway or surrounded them as they walked to the clinic. New York City Mayor Michael Bloomberg signed the law in April. Joan Malin, president and CEO of Planned Parenthood of New York City, said the group is "not against people demonstrating. But there is a line between freedom of speech and harassment and bullying" (Bosman, New York Times, 6/6).
The Royal College of Pathologists welcomes the Royal College of Physicians" report into the future
The United Nations World Food Programme (WFP) thanked contributors for enabling a swift response to the humanitarian crisis
The NAO today published a major report, "Supporting people with autism through adulthood". HOPE, the charity for adults with autism and learning disabilities, sees this important report as a blueprint for improving the lives of people with autism.
Brookdale Care, the specialist provider of care services for
Royal Philips Electronics (NYSE: PHG, AEX: PHI) introduced the Trilogy100 portable at-home life-support ventilator. The highly versatile, lightweight (11 lb / 5 kg) device marks a milestone in home ventilation from a recognized leader in respiratory care. Respironics first introduced bi-level positive airway pressure for noninvasive ventilation nearly 20 years ago.
According to a research abstract that will be presented on Wednesday, June 10, at SLEEP 2009, the 23rd Annual Meeting of the Associated Professional Sleep Societies, caffeine use prevents increased risk taking that occurs after several nights of total sleep deprivation.
Employees who often go to work despite feeling sick have higher rates of future work absences due to illness, according to a study in the June Journal of Occupational and Environmental Medicine, official publication of the American College of Occupational and Environmental Medicine (ACOEM).
House Republicans on Wednesday sent President Obama a letter urging "open and constructive dialogue across party lines" on health care reform and calling on him to maintain current restrictions on federal funding of abortion services, Politico reports. The letter, signed by House Minority Leader John Boehner (Ohio), House Minority Whip Eric Cantor (Va.), House Republican Conference Chair Mike Pence (Ind.) and six other Republican House members, outlines the Republicans" positions on health care reform. It says achieving those objectives "can be accomplished through health reform that maintains current law provisions regarding restrictions on federal funding of abortion services, restricts federal funds from flowing to abortion providers and does not impose mandates either on insurance carriers or medical providers to participate in activities that violate their religious and moral beliefs."The letter says that Republicans have several "areas for potential common ground on health care reform." In all, it mentions the phrase "common ground" four times in eight paragraphs, Politico reports (Allen, Politico, 5/13).
Scientists at The Feinstein Institute for Medical Research and a team of collaborators from across the country have identified a new risk factor gene for rheumatoid arthritis. The paper will be published in Nature Genetics and the finding brings light to the nature of the disease. The gene, dubbed REL, is a member of the NF-íşB family, important transcription factors that have many roles in the body. The NF-íşB family seems to have a big hand in regulating the body"s immune response as well.
A new, easy-to-perform method for detecting both seasonal influenza A virus and the emerging H1N1 swine-derived influenza A virus in human clinical samples offers a fast, sensitive, and cost-effective diagnostic test that runs on standard laboratory equipment. This timely and broadly applicable molecular technique is described in an article published online ahead of print in Vector-Borne and Zoonotic Diseases, a peer-reviewed journal published by Mary Ann Liebert, Inc. The article is available free online at http://www.liebertpub.com/vbz.
Residential childcare and fostering agency, Perpetual Care, and the University of Central Lancashire"s School of Nursing & Caring Sciences are jointly developing an introductory workshop on the ground-breaking Nurtured Heart Approach, which seeks to improve social and educational outcomes for many children and young people. Experts from UCLan and Perpetual are currently designing an awareness workshop, which will provide an overview of the approach, examine existing US research findings and explore its potential role in UK residential childcare and fostering, particularly in the light of revised NICE guidelines relating to children with ADHD. The first session is scheduled at UCLan"s Preston campus in late June this year and should be of interest to registered social workers, local authority placement officers and other social care and health professionals concerned with the well-being of challenging young people.
According to a research abstract presented at SLEEP 2009, the 23rd Annual Meeting of the Associated Professional Sleep Societies, patients suffering from chronic primary insomnia (PIs) have higher levels of brain activation compared to normal sleepers during a working memory test.
Older women who take hormone therapy to relieve menopausal symptoms may get the added benefit of reduced body fat if they are physically active, according to a new study. The results were presented at The Endocrine Society"s 91st Annual Meeting in Washington, D.C.
Clinicians from the Centre hospitalier de l"Universitçİ de Montrçİal (CHUM) have perfected an operation, which was previously considered too dangerous, to control refractory insular epilepsy, using an innovative microsurgery technique. According to a study published as the feature article in the latest issue of the Journal of Neurosurgery, the new surgical technique is both safe and beneficial for patients.
The genes that regulate human circadian rhythm, or "the body clock", are significantly disturbed in individuals with arthritis, according to the results of a new study presented at EULAR 2009, the Annual Congress of the European League Against Rheumatism in Copenhagen, Denmark. Notably, a specific genetic pathway has been identified as responsible for interactions between the genes that regulate the body clock and those that may worsen symptoms of arthritis.
Three pseudo kinases of the Tribbles family have been recently recognized, which include TRB1, TRB2 and TRB3. Recent research has found that the expression of hepatic TRB3 increased in a rat model of diabetes. TRB3 could block the insulin signaling pathway through inhibiting Akt activation, which contributes to insulin resistance.
First year to be offered live and online
Elsevier, the world-leading publisher of scientific, technical and medical information products and services, has announced the launch of the online version of the Chinese Journal of Natural Medicines (CJNM). Established in 2003, the Chinese Journal of Natural Medicines is now available for the first time in English on ScienceDirect.
New research from Jefferson Hospital for Neuroscience (JHN) may redefine how Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) is diagnosed. Eduardo De Sousa, M.D., assistant professor of Neurology at Jefferson Medical College of Thomas Jefferson University, and director of the Electrodiagnostic Neuromuscular Lab at JHN, led the study which looked at the number of demyelinating features that are needed to differentiate between CIDP, Amyotrophic lateral sclerosis (ALS, or Lou Gehrig"s disease) and diabetic neuropathy. His research suggests a minimum number of three demyelinating features can be used to positively identify CIDP in a patient. CIDP is a neurological disorder characterized by progressive weakness and impaired sensory function in the legs and arms. It affects about 50,000 people in the United States. The study, available in the current edition of the Journal of Clinical Neuromuscular Disease, may help doctors more effectively diagnose and treat CIDP.
The virus that causes winter vomiting disease invades cells by attaching to particular sugar molecules on the surface of the cells. This is the conclusion of a thesis presented at the Sahlgrenska Academy, University of Gothenburg, Sweden. This result may be an important step in the development of a drug against the regular hospital-based epidemics caused by the virus.
Exposure during pregnancy to the chemical bisphenol A, or BPA, found in many common plastic household items, is known to cause a fertility defect in the mother"s offspring in animal studies, and now researchers have found how the defect occurs. The results of the new study will be presented Saturday at The Endocrine Society"s 91st Annual Meeting in Washington, D.C.
New data presented at the American Diabetes Association (ADA) 69th Annual Scientific Sessions showed that initial treatment with "Janumet"* (sitagliptin/metformin) provided significantly greater blood sugar improvements in drug-naçŻve** patients with type 2 diabetes, compared with metformin alone.[i]
In a study that sheds light on how insurance coverage may drive health care and may reveal an unexpected result for the uninsured, a team of Yale School of Medicine and Yale-New Haven Children"s Hospital physicians has found that babies from uninsured families who are born with congenital defects are far more likely than those whose families have insurance to be transferred out of the large community hospitals where they are born and into children"s hospitals for corrective surgery.
The Automation Partnership (TAP), a world leader in the design and development of innovative advanced automation for life science applications, announced it is collaborating with world leading academics on the prestigious, Technology Strategy Board funded, RAFT (Rapid Automated Fabrication of Tissues) Project to develop and commercialise novel technology for rapid production of 3D tissues, which have the potential to transform drug discovery and regenerative medicine.
Though it looks like a tiny purple blowtorch, a pencil-sized plume of plasma on the tip of a small probe remains at room temperature as it swiftly dismantles tough bacterial colonies deep inside a human tooth. But it"s not another futuristic product of George Lucas" imagination. It"s the exciting work of USC School of Dentistry and Viterbi School of Engineering researchers looking for new ways to safely fight tenacious biofilm infections in patients - and it could revolutionize many facets of medicine.
The United States is becoming a nation of haves and have-nots when it comes to tobacco control, according to a comprehensive publication on cigarette smoking prevalence and policies in the U.S. which has just been released.
The Washington Times on Friday examined how President Obama"s "former campaign apparatus is cranking up a full-tilt drive for passage of a health care overhaul this year" by "tapping his 13-million-strong e-mail list" for financial contributions to fund advertising efforts, hire staff and open election-style offices. The group -- launched in January as Organizing for America, or OFA2, a unit under the Democratic National Committee -- sent supporters an e-mail this week asking them for their time and money to fight "special interest lobbyists and partisan ideologues" that might attempt to "water down" health care reform. Mitch Stewart, the group"s executive director, wrote that contributions would be used to organize "local educational events" and to "bring constituent voices straight to Congress, and make sure real life stories are heard louder than the lobbyists" spin" (Bellantoni, Washington Times, 5/15). Single-Payer System Not on Table, Obama Says
Emory University researchers have identified a surprising mechanism in the brains of mother mice that focuses their awareness on the calls of baby mice. Their study, published June 11 in Neuron, found that the high-frequency sounds of mice pups stand out in a mother"s auditory cortex by inhibiting the activity of neurons more attuned to lower frequency sounds.
EyeIC, an innovator of eye care solutions for ophthalmologists and optometrists, announced today that its MatchedFlicker(TM) technology has received FDA 510(k) clearance from the United States Food & Drug Administration (FDA). MatchedFlicker is a device-agnostic, software-only solution that uses time series retinal photographs to help doctors monitor the advent and progress of glaucoma faster and with accuracy now available to only a few experts.
Ziehm Imaging is proud to announce that the United States Food and Drug Administration (FDA) has given 510k clearance for the latest innovative mobile C-arm from Ziehm Imaging, the Ziehm Vision(R) RFD, for marketing and sales within the United States. Designed for use in endovascular surgery, interventional cardiology and interventional radiology, the Ziehm Vision RFD mobile C-arm combines the latest flat-panel technology and a true fully digital imaging chain with a compact design that delivers exceptional image quality. During demanding procedures physicians will benefit from improved visualization, workflow and reduced radiation dose.
President Obama"s choice for the State Department"s global AIDS coordinator position, Eric Goosby, testified on Tuesday at a confirmation hearing with the Senate Foreign Relations Committee, VOA News reports. Goosby would work to continue PEPFAR"s success, and "says he will emphasize prevention if he is confirmed by the Senate," VOA News writes.
A new survey released shows that 3 out of 4 (75%) adults with high blood pressure are not at all familiar with the role of the renin system(1) -- a key regulator of blood pressure in the body.(2) Yet, about 9 out of 10 adults with high blood pressure (89%) both believe the condition is a cause for concern and want to understand what is going on in their body that is causing it.(1) The Omnibus survey, sponsored by Novartis Pharmaceuticals Corporation, was conducted by Harris Interactive(R) among more than 2,400 US adults ages 18+, more than 700 of whom said they have high blood pressure.(3)
A Selection of Opinions and Editorials
Trust for America"s Health (TFAH) and the Robert Wood Johnson Foundation (RWJF) released a new public opinion survey today which finds that Americans rank prevention as the most important health care reform priority, and overwhelmingly support increasing funding for prevention programs to reduce disease and keep people healthy.
Havel"s Incorporated, a Cincinnati-based distributor of unique needle devices, has partnered with CHS, Canadian Hospital Specialties, which will become the exclusive distributor of Havel"s EchoStim(R) and EchoBlock(R) Ultrasound Needles throughout Canada.
An analysis of the latest peptide genomic data for the H1N1 influenza virus indicates that the current global outbreak of H1N1 is increasing in its capacity for lethality. The new sequence data on PubMed of the past two weeks through June 10, 2009 showed an increase in the Replikin Count* of the Replikin Lethality Gene in the pB1 genomic area from a mean of 2+/-0.2 in 2008 to a mean of 3.2+/-3.7 in 2009 (p
A new technology that revolutionizes the way low back pain is diagnosed and treated, while also significantly reducing healthcare costs, has been introduced by SpineMatrix(R) Inc., an Akron, Ohio-based medical technology company that specializes in advanced spinal diagnostics.
Researchers at The Wistar Institute have defined a key target of an evolutionarily conserved protein that regulates the process of aging. The study, published June 11 in Nature, provides fundamental knowledge about key mechanisms of aging that could point toward new anti-aging strategies and cancer therapies.
Medtronic, Inc (NYSE: MDT) announced the launch of the Shock-Less clinical trial. This trial will identify ways physicians can improve the quality of care for patients through optimal application of device-based tools designed to reduce unnecessary shocks in patients with implantable cardioverter-defibrillator (ICD) and cardiac resynchronization therapy-defibrillator (CRT-D) devices. Specifically, the Shock-Less study aims to create evidence that will increase the use of programming tools that reduce unnecessary shocks including features on Medtronic devices, such as Medtronic"s exclusive Lead Integrity Alert™ (LIA) and Anti-Tachycardia Pacing (ATP) During Charging™.
After the murder of abortion provider George Tiller and the closure of his Wichita, Kan., clinic, residents of the city face about a three-hour drive to the nearest abortion provider, a distance experts say is not uncommon for access to abortion services in southern and midwestern states, the Wichita Eagle reports. Jenny O"Donnell of the Abortion Access Project said that southern and midwestern states have the heaviest restrictions on abortion, adding that "substantial populations don"t have an abortion provider" in states such as Mississippi and Arkansas. According to 2005 statistics from the Guttmacher Institute, 87% of U.S. counties have no abortion provider; the figure rises to 94% of counties in the Midwest and 96% of counties in Kansas. The number of abortion providers in Kansas declined from 15 in 1992 to seven in 2005, while the number of providers nationwide dropped from 2,380 to 1,787 over the same time period, according to Guttmacher. Experts say the decline is the result of several factors, including public pressures, increased regulation that has driven up the cost and complexity of providing abortion and a general trend in the health care industry toward consolidated, more specialized practices.Vicki Saporta, president and CEO of the National Abortion Federation, said that the decrease in the number of abortion providers is misleading on some levels. The decline primarily has occurred among hospitals and small providers who perform a few procedures a year, while major clinics that specialize in abortion have remained essentially stable, Saporta said. Peter Brownie, executive director of Planned Parenthood of Kansas and Mid-Missouri, said that the group"s clinics have experienced an increase in contacts from women from south-central Kansas since Tiller"s clinic closed a little more than one week ago. He added, "At the present time, there"s no place between Denver and Kansas City where a woman can obtain abortion care. That"s a significant barrier for women throughout the state that have that need." NAF has established a national hotline to offer referrals for women who have to make new arrangements for abortion care because of the closure of Tiller"s clinic, Saporta said (Lefler, Wichita Eagle, 6/9).
Tens of thousands of people yesterday took to the streets in
Researchers at UMDNJ-Robert Wood Johnson Medical School are a step closer to treating, and perhaps preventing, muscle damage caused by disease and aging. In their study, published in the June issue of Journal of Biological Chemistry, the scientists have linked the newly discovered protein MG53 to a pathway that repairs human muscle tissue along with the proteins caveolin-3 (Cav3) and dysferlin. Prior to this study, the underlying interactions that inhibited membrane repair in muscle tissue were unknown. Linking these proteins creates a mechanism that allows damaged membranes to be repaired, which may transform treatment for patients who suffer from severe complications of diseases such as muscular dystrophy, as well as cardiovascular disorders and conditions related to advancing age.
He"s already shown that a blue curing light stunts tumor growth. Now the senior in the Medical College of Georgia School of Dentistry is trying to identify the proteins responsible.
The American Pharmacists Association (APhA) applauds the report by The White House Council of Economic Advisers (CEA) which provides a comprehensive analysis of the economic impact of health care reform.
Commenting in response to today"s report from the NHS Confederation on the financial prospects for the NHS, The King"s Fund"s Chief Executive Niall Dickson said:
If you are pregnant and your mate complains your frequent snoring is rattling the bedroom windows, you may have bigger problems than an annoyed, sleep-deprived partner.
Commenting on the announcement by European Federation of Public Service Unions (EPSU) and the European Hospital and Healthcare Employers Association (HOSPEEM) of an EU-wide agreement set to prevent 1 million medical sharps injuries per year, Dr Peter Carter, Chief Executive & General Secretary of the Royal College of Nursing (RCN), said:
Paul Farmer -- founder of Partners in Health and vice chair of the Department of Global Health and Social Medicine at Harvard Medical School -- said he is in discussions with the State Department about a possible Obama administration appointment to coordinate U.S. global health initiatives, the Boston Globe reports. Farmer made the announcement Monday during a meeting with HMS faculty. Farmer said that he has not decided whether he will accept the appointment if he receives a formal offer but that he is considering it, according to the Globe. The Globe reports that it was unable to confirm whether Farmer is being considered for a full-time policy position or for an advisory role or if the appointment would be a new or existing position. Several top positions at USAID -- including administrator, deputy administrator and the assistant administrator in charge of global health are vacant, the Globe reports. These positions are presidential appointments and would require Senate confirmation. In addition, Farmer could be discussing health policy positions with the State Department. Farmer did not respond for requests seeking comment. PIH and HMS also declined comment. A spokesperson at the State Department would not discuss personnel discussions that are in progress or possible new positions. Laurie Garrett, a global health policy specialist at the Council on Foreign Relations, said the administration"s announcement last week of a $63 billion, six-year initiative that aims to address HIV/AIDS, tuberculosis, malaria and other illnesses could allow new appointees the opportunity to make a significant impact in U.S. global health policy. Garrett, who has known Farmer for several years, added that she would be surprised if he is considering a government position in part because of his extensive involvement with PIH (Smith, Boston Globe, 5/15).
Body Mass Index (BMI) varies as a function of habitual sleep duration, according to a research abstract presented at SLEEP 2009, the 23rd Annual Meeting of the Associated Professional Sleep Societies.
Annette Langer-Gould, MD, PhD (Stanford University) and colleagues followed 32 pregnant women with MS, assessing their disease and breastfeeding status at intervals out to 12 months after giving birth. They found that women who breastfed their babies exclusively (without giving supplemental bottles) for at least the first two months post-partum were less likely to have an MS relapse than those who did not breastfeed or who did not breastfeed exclusively during the first two months (36% who breastfed exclusively experienced a relapse, as compared to 87% who did not breastfeed or who supplemented with formula).
Scientists have identified for the first time a mechanism by which nanoparticles cause lung damage and have demonstrated that it can be combated by blocking the process involved, taking a step toward addressing the growing concerns over the safety of nanotechnology.
Scientists from the Breakthrough Breast Cancer Research Centre based at the Institute of Cancer Research have shown for the first time that it is possible for one drug to simultaneously attack cancer cells in two completely different ways. Researchers now hope this discovery could lead to further two-in-one treatments - meaning breast cancer patients could potentially need to take fewer drugs to treat tumours in the future.
OCD-UK, the leading national charity for people with Obsessive-Compulsive Disorder with the support of a grant from Comic Relief has announced a year long research project to understand and evaluate if treatment guidelines have had a positive impact on providing treatment for people with OCD across the UK.
Scientists have discovered exactly how some bacteria act to protect themselves when they are threatened or under attack.
ENT and Allergy Associates, LLP (ENTA), is pleased to announce the formation of OASIS (i.e., Otolaryngology, Allergy Specialty Insurance Services), a separate company that will be a vehicle to provide Otolaryngology and Allergy Specific medical malpractice coverage. OASIS, which will be domiciled in the State of Vermont, is the first RRG to provide medical malpractice coverage exclusively to ENT physicians and Allergists. ENTA decided to embark on this path as a means of stabilizing its malpractice premiums in the face of mounting deficits among the State"s largest carriers and the failure of the legislature to pass any meaningful tort reform. These factors will most likely result in substantial premium increases well into the future. In addition, ENTA, now a 96 physician practice, will be able to focus on controlling the risks unique to its specialty to ensure patient safety and physician compliance with its risk management policies.
Emergent BioSolutions Inc. (NYSE:EBS) announced that its flagship product, BioThrax® (Anthrax Vaccine Adsorbed), has been granted a shelf life extension from 3 to 4 years by the U.S. Food and Drug Administration (FDA). Based on this approval, Emergent has achieved a contract milestone warranting a payment of approximately $30 million for doses previously delivered to the Strategic National Stockpile (SNS) under the terms of the company"s existing BioThrax procurement contracts with the Department of Health and Human Services (HHS). This amount is expected to be recognized as revenue in the second quarter of 2009. In addition, FDA approval of 4-year expiry dating results in an immediate price increase for the future delivery of BioThrax doses under the current contract as well as under the follow-on multi-year contract, valued at $405 million, for the delivery of 14.5 million doses of BioThrax.
Colorectal cancer (CRC) is one of the most common cancers in China. Although the association between the epidemiological factors and sporadic colorectal cancer has been studied, the relation between smoking, alcohol drinking, family history of cancer, body mass index (BMI) and sporadic colorectal cancer still remains uncertain. So it is important to investigate the role of these factors in the development of sporadic colorectal cancer.
Checkpoint with forkhead and ring finger (CHFR) is a mitotic stress checkpoint gene whose promoter is frequently methylated in various kinds of cancer. In gastric cancer, CHFR promoter hypermethylation has been reported to lead to chromosome instability (CIN) and genetic instability is one of the hallmarks of human cancer.
Hepatocellular carcinoma (HCC) is the fifth most common malignancy worldwide and the third leading cause of cancer-related deaths. Type 2 diabetes mellitus has been associated with HCC. However, the relationship between type 2 diabetes mellitus and the underlying liver cirrhosis, and the effects of antidiabetic therapy on HCC risk have not yet been fully evaluated.