Medical Devices
New research, published in The Lancet Oncology, has found that combining human papillomavirus (HPV) testing with routine liquid-based cytology (LBC) screening does not increase the detection of cervical cancer compared with LBC screening alone. The trial funded by the National Institute for Health Research Health Technology Assessment (NIHR HTA) programme aimed to determine whether testing for HPV in the cervix might increase the effectiveness of the cervical screening programme.
A group of doctors in Pittsburgh have developed the Computer Assessment of Mild Cognitive Impairment (CAMCI) to identify cognitive difficulties easily and reliably. In an article in the March issue of Postgraduate Medicine entitled "Computer Assessment of Mild Cognitive Impairment," the program creators detail the procedures and the benefits of the new test, which they claim is sensitive enough to notice the smallest amount of forgetfulness. By conducting a controlled study with 524 people >60 years old, they were able to demonstrate the ease and effectiveness of the testing system.
California Gov. Arnold Schwarzenegger (R) outlined two budget proposals to address the state"s budget problems, and both plans would affect health care, the Los Angeles Times reports. The first proposal addresses the situation if California voters approve a set of special ballot measures intended to provide funds for fiscal year 2009-2010. The state would still face a $15.4 billion budget deficit even if voters approve the measures, and the second proposal addresses that scenario (Rothfeld, Los Angeles Times, 5/15). The governor proposed $750 million in cuts to Medi-Cal, the state"s Medicaid program, that would reduce eligibility and provider rates. The state would need to seek a federal waiver to implement the cuts. The governor also proposed eliminating eligibility for non-emergency Medi-Cal benefits for documented immigrants (Colliver, San Francisco Chronicle, 5/15). Spending for centers that provide services to people with developmental disabilities would be cut by $234 million (Zapler, San Jose Mercury News, 5/14).If voters do not approve three ballot measures, Schwarzenegger outlined $800 million in additional cuts to health and human services programs, including a proposal to eliminate Healthy Families coverage for about 225,000 children. Healthy Families is California"s CHIP (Yi et al., San Francisco Chronicle, 5/15).
"President Barack Obama on Wednesday rejected the idea of fully taxing Americans" employer-provided health insurance benefits, but suggested he might be persuaded to tax so-called Cadillac coverage ... in the interest of a compromise with Congress," McClatchy/The Star-Telegram reports. The President, speaking at a "town hall-style event" taped at the White House and aired on ABC News, "said he would prefer to pay for expanded coverage by eliminating some deductions for higher-earning taxpayers but that "there"s going to have to be some compromise." The President "said he understands Americans" trepidation about changing the system: "They know that they"re living with the devil, but the devil they know they think may be better than the devil they don"t." He said any reform would be phased in, not happen overnight" (Talev and Lightman, 6/24).
A Lifeline For Primary Care The New England Journal of Medicine
A three-year initiative launched last year by the New York City Department of Health and Mental Hygiene to test every adult in the Bronx for HIV has boosted testing by 28 percent, according to city health officials, the New York Times" blog "City Room" reports. The "Bronx Knows" campaign began with an effort to make voluntary HIV testing routine in emergency departments and clinics, where city officials said, "cumbersome consent procedures required by state law have deterred doctors from offering the tests," according to "City Room" (Chan, "City Room," New York Times, 6/24). The initiative - which involves clinics, hospitals and community organizations - tested nearly 160,000 Bronx residents in the past 12 months (United Press International, 6/24). The city also is participating in National HIV Testing Day on Saturday ("City Room," New York Times, 6/24).
The North Carolina Senate on Tuesday voted 25-21 to approve a bill (S. 221) that would require public school systems in the state to offer a sex education curriculum that includes information on abstinence, contraceptives and sexually transmitted infections, the Winston-Salem Journal reports. Currently, only two public school systems in the state offer comprehensive sex education, with the rest teaching abstinence-only curricula. Under the bill, parents would be able to have their children removed from the comprehensive portions of the program (Romoser, Winston-Salem Journal, 6/24). The bill would apply to students in seventh through ninth grade (AP/Virginian-Pilot, 6/23).The bill includes several changes from an earlier version that was approved by the state House. The measure now returns to the House, where lawmakers will decide whether to approve the Senate"s changes (Winston-Salem Journal, 6/24).
Hundreds of health care leaders from throughout the state gathered Wednesday evening in Lake George as the Healthcare Association of New York State (HANYS) presented its 30th annual Distinguished Service Award, its highest honor, to New York State"s health care auxiliaries. Since 1979, HANYS has awarded the Distinguished Service Award to individuals who demonstrate their extraordinary commitment to improving health care through service to their community.
More than 50 further education colleges are set to make redundancies leading to the closure of a huge number of nurseries, according to UNISON, UCU and NUS.
In an article published in the June 25th edition of the journal Neuron, researchers at the Hotchkiss Brain Institute, University of Calgary, have found that synaptic plasticity, long implicated as a device for "change" in the brain, may also be essential for stability.
It is now possible to engineer tiny containers the size of a virus to deliver drugs and other materials with almost 100 percent efficiency to targeted cells in the bloodstream.
Biotechnology Industry Organization (BIO) President and CEO Jim Greenwood issued the following statement regarding the letter sent yesterday from the Obama Administration to House Energy and Commerce Committee Chairman Henry Waxman regarding biosimilars:
In the bustling economy of the cell, little bubbles called vesicles serve as container ships, ferrying cargo to and from the port - the cell membrane. Some of these vesicles, called post-Golgi vesicles, export cargo made by the cell"s protein factory. Scientists have long believed that other, similar vesicles handle the reverse function, importing life-supporting nutrients and proteins through an independent process. By using a finely honed type of microscopy to more precisely examine these transactions, new research shows the processes are not as independent as assumed: certain molecules handle cargo moving in both directions. Like stevedores, they"re involved in both loading and unloading the cell"s container ships.
The recent decline in invasive breast cancer in the US was significantly less pronounced in the poor and those who live in rural areas. Researchers writing in the open access journal BMC Medicine suggest this may be due to varying reductions in the numbers of women taking hormone therapy (HT).
Mice who inherit a particular chromosomal duplication from their fathers show many behaviors associated with human autism, researchers report in the June 26th issue of the journal Cell, a Cell Press Publication. The duplicated chromosomal region in mice is the equivalent of human chromosome 15q11-13, the most frequent cytogenetic abnormality observed in autism, accounting for some five percent of all cases.
The University of Texas Health Science Center at Houston has received a $412,500 federal stimulus grant for Parkinson"s disease research, the university announced today. It is the university"s first federal stimulus grant.
The new 4th generation rapid HIV diagnostic test - Determine® HIV 1/2 Ag/Ab Combo - from Inverness Medical is capable of detecting HIV infection several days earlier than HIV antibody only tests and is ideal to help diagnose and screen for early HIV infection. The ability of this test to enhance the diagnosis of those with acute HIV infection will provide additional benefits in HIV prevention programs and ultimately contribute to a reduction in the spread of HIV. Inverness Medical will be showcasing the new Determine Combo test at the International AIDS Society Conference 2009 in Capetown, South Africa, 19-22 July on stand #203.
HearAtLast Holdings, Inc. (PINKSHEETS: HRAL), a leading provider of suitable affordable solutions to clients with hearing needs in the billion dollar hearing loss market, announced that in keeping with its tradition of bringing innovative new products to consumers, the Company announces the unveiling of breakthrough hearing products based on the Neuro-Compensator™ algorithm technology from VitaSound Audio.
Understanding the molecular signals that guide early cells in the embryo to develop into different organs provides insight into ways that tissues regenerate and how stem cells can be used for new therapies. With regenerated cells, researchers hope to one day fill the acute shortage in pancreatic and liver tissue available for transplantation in cases of type I diabetes and acute liver failure.
As of January 2010, the Bulletin de la Sociçİtçİ de Pathologie Exotique will join Springer"s publishing program. Founded in 1908 by Nobel Laureate Louis-Alphonse Laveran, the society celebrated its centenary last year. It plays a major role in the promotion of health issues and information on tropical pathology.
Many people who test positive for HIV are diagnosed late in the course of their infection when treatment might be less effective, according to a report published Thursday in CDC"s Morbidity and Mortality Weekly Report, Reuters Health reports. The report looked at data on people who were diagnosed with HIV from 1996 to 2005 and found that 45 percent had developed AIDS within three years of their initial HIV diagnosis, 38.3 percent within one year and an additional 6.7 percent within the next two years (Reuters Health 6/25). R. Luke Shouse of CDC"s Division of HIV/AIDS Prevention in the National Center for HIV/AIDS, Viral Hepatitis, STD and TB Prevention, said, "This means that they may have unknowingly transmitted HIV. It also means that there is a time when they had HIV when they were not under appropriate medical care, so there are missed opportunities for prevention and care." A separate CDC report also published yesterday found that 22.3 percent of high school students who are sexually active and 12.9 percent of all students have been tested for HIV (Reinberg, HealthDay/KATC.com, 6/25).
Hot or not? Men agree on the answer. Women don"t.
A specific biomarker, a protein released by dying tumor cells, has been identified as an effective tool in an animal model to gauge the response to a novel gene therapy treatment for glioblastoma mulitforme. The finding, reported in the July 1 issue of Clinical Cancer Research, paves the way for a Phase 1 clinical trial expected to begin in late 2009.
Diabetes patients who are hospitalized for non-critical illnesses, and develop hypoglycemia while hospitalized, are likely to remain hospitalized longer and face greater risk of mortality both during and after hospitalization, according to a study published in the July issue of Diabetes Care.
The number of local health services implementing NICE"s fertility guideline and offering three cycles of IVF treatment to couples who are unable to conceive naturally has increased significantly in the past year, according to a new survey published by the Department of Health. According to these new figures, more than a quarter of primary care trusts now offer the full number of cycles recommended by NICE- this figure is up from five per cent in 2007.
A Vanderbilt chemist and a biomedical engineer have teamed up to develop a respiratory virus detector that is sensitive enough to detect an infection at an early stage, takes only a few minutes to return a result and is simple enough to be performed in a pediatrician"s office.
Data presented yesterday, in Budapest, demonstrated that add-on treatment with the novel, once-daily anti-epileptic Zebinix®* (eslicarbazepine acetate; ESL) resulted in a marked and sustained decrease in seizure frequency over the long-term. Results from the one-year extension of a pivotal Eslicarbazepine Acetate phase III study were presented at the International Congress for Epilepsy in Budapest, Hungary. Patients not controlled with existing anti-epileptic drugs who were given eslicarbazepine acetate as an add-on treatment experienced a mean reduction in seizure frequency of more than 61% (95%CI: -68.2%, -55.5%). Nearly 65% of patients were classified as responders, meaning that they had achieved at least a 50% reduction in seizure frequency with Zebinix® treatment1.
Medtronic, Inc. announced that DFine Europe GmbH has accepted the terms of a preliminary injunction granted to Medtronic GmbH by a German Competition Court. The preliminary injunction stops DFine Europe GmbH from using certain misleading marketing claims related to Medtronic"s Kyphon® Balloon Kyphoplasty products in Germany.
Medicare beneficiaries" activities of daily living (ADL) improved in their first year of the Medicare Part D senior prescription drug plan, according to a ground-breaking study presented at the Annual AcademyHealth meetings in Chicago today.
In a leading medical journal this week US researchers describe the 90-year history of swine flu and warn about working with "freezer" viruses,
Antares Pharma, Inc. (NYSE Amex: AIS) and the Population Council announced preliminary positive results from the Phase 2 trial for a novel contraceptive gel containing the progestin Nestorone and the bio-identical estrogen estradiol (NES/E2) utilizing the Antares ATD (advanced transdermal delivery) gel system.
The Journal of Nuclear Medicine (JNM)-the flagship publication of SNM-has been ranked the top medical imaging journal worldwide, according to new data released in the 2008 Journal Citation Reports(c) published by Thomson Reuters. The top ranking recognizes JNM"s exceptional quality and increasing influence as an academic and professional re.
The high-intensity training undertaken by triathletes has a significant impact on the quality of their sperm, the 25th annual conference of the European Society of Human Reproduction and Embryology heard 29 June. Professor Diana Vaamonde, from the University of Cordoba Medical School, Cordoba, Spain, said that the triathletes who did the most cycling training had the worst sperm morphology.
A long-term care program could produce some needed dollars, at least in the short range, CQ Politics reports: "A new insurance program for long-term care that Democrats have included in a Senate health overhaul bill would produce about $58 billion in revenue for the government over the next 10 years, according to the Congressional Budget Office, helping to offset the cost of the legislation. Democrats acknowledge that spending in the long-term care program would increase after 10 years and that it likely would not remain a very profitable enterprise for the government. It is even possible, they say, that the program could become insolvent; in that case, the secretary of Health and Human Services would be authorized to close its enrollment. "The CBO says that premiums would have to rise significantly higher than Democrats have assumed for the program to remain financially sound."
"Major medical organizations are urging health committees in the House and Senate to make comparative-effectiveness research a key component of healthcare reform," Modern HealthCare reports. The Senate Health, Education, Labor and Pension Committee"s bill "plans for a new federal center on health outcomes research was seen by some GOP members as a possible means to ration healthcare." But "a letter, co-signed by the American Medical Association and more than 60 other groups, countered that comparative-effectiveness research would not lead to "cookbook" medicine or rationing of expensive forms of care" (Lubell, 6/26).
President Obama on Saturday released a statement marking National HIV Testing Day that urged U.S. residents to get tested for HIV and work toward reducing the spread of the virus, Bloomberg/Arizona Daily Star reports (Bloomberg/Arizona Daily Star, 6/28). Obama said in the statement, "Each of us must take responsibility for reducing our risk of acquiring or transmitting HIV and for supporting affected individuals and communities. This means getting tested for HIV and working to end the stigma and discrimination people living with HIV face." The White House also released a video message with Obama"s statement (White House release, 6/27).
Fireworks are a traditional part of America"s celebration of Independence Day on July 4.
Mental health services could be improved by
Whether it"s the summer grass that tickles your feet or the red Bordeaux smacking on your palette, nearly every part of the world around you carries special chemical markers. These markers, called isotopes, can tell scientists where the molecules that compose a substance are from, where they traveled, and what happened to them along the way. But doing these analyses has been complex and costly. Now, Stanford chemists have developed a new method to make isotopic analysis easier and less expensive.
The RCN has responded to the recent (29 June) publication of Building Britain"s Future with Director of RCN England, Tom Sandford, saying of the two week target to see a cancer specialist:
Potential new drugs: 970 million and still counting
Scientists discover novel mechanism that increases the risk of common colorectal cancer
Achaogen, a clinical stage biopharmaceutical company addressing the issue of multi-drug resistant bacterial infections through the discovery and development of innovative broad-spectrum antibiotics, announced today the presentation of research on aminoglycoside (AG) resistance trends and comparative AG toxicities at the 19th Annual European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), being held May 16-19, 2009 in Helsinki, Finland.
Baxter International Inc. (NYSE:BAX) announced today a definitive agreement with Edwards Lifesciences Corporation (NYSE:EW) under which Baxter will acquire certain assets related to Edwards" hemofiltration product line, also known as Continuous Renal Replacement Therapy (CRRT). The transaction is expected to close in the third quarter of 2009, pending regulatory approvals.
Speaking at the Annual Conference of the British Medical Association (BMA), Dr Peter Terry, chairman of the BMA Scotland urged MSPs to put party politics aside and stand together to improve health. He also underlined the need for legislation on the price of alcohol as an effective measure to tackle Scotland"s drink problem.
Pancreatitis is often a fatal condition, in which the pancreas digests itself and surrounding tissue. Scientists have previously found that alcohol can trigger the condition by combining with fatty acids in the pancreas, which leads to an excessive release of stored calcium ions. Once calcium ions enter cell fluid in the pancreas it activates digestive enzymes and damages the cells.
New data presented at the British Society for Allergy and Clinical Immunology (BSACI) annual meeting demonstrate that Grazax® is the first tablet treatment to provide sustained disease control in patients with grass pollen rhinoconjunctivitis (hay fever) after the treatment period ended. This is the first time disease modification by sublingual allergy immunotherapy tablets has been achieved; effectively re-setting the immune system to reduce future allergic reactions to grass pollen.
Amira Pharmaceuticals, Inc. announced initial positive data from a Phase 1 clinical study of AM211, the company"s oral selective antagonist of the DP2 (also known as CRTH2) receptor.
Even at very high doses, gadolinium-based contrast agents alone are not sufficient to cause nephrogenic systemic fibrosis (NSF) in patients with kidney problems, according to a study performed at the Mayo Clinic Florida, Jacksonville, FL. NSF is a rare and serious syndrome that leads to fibrosis of the skin, joints and even internal organs. Some research indicates NSF is caused by gadolinium-based contrast agents that are commonly used today during MR procedures.
Doctors at a heart center in the US announced yesterday that the first of 24 heart attack patients taking part in a clinical trial has successfully
A new survey from the Stanford University School of Medicine suggests that a significant number of Asian Americans living in California adopt unhealthy sun-exposure behaviors as they become more westernized. The findings underscore a need for increased skin-health awareness on the part of primary care physicians, dermatologists and people of Asian ancestry, who may incorrectly assume that pigmented skin and hair protect against skin cancer.
CytRx Corporation (NASDAQ: CYTR), a biopharmaceutical research and development company engaged in the development of high-value human therapeutics, provided a favorable progress update for its ongoing Phase 2 STAR-1 registration clinical trial to evaluate the efficacy and safety of orally administered tamibarotene as a third-line treatment for acute promyelocytic leukemia (APL).
BioSante Pharmaceuticals, Inc. (NASDAQ: BPAX), which is developing a testosterone gel (LibiGel®) to treat hypoactive sexual desire disorder (HSDD) in women, is pleased to comment on results in a paper published in the July issue of The Journal of Sexual Medicine showing testosterone has no effect on the incidence of invasive breast cancer among menopausal women who use testosterone to improve sexual function.
The provision of medical care and the evacuation of the trapped and
Whether a monkey is looking to the left or merely watching another monkey looking that way, the same neurons in his brain are firing, according to researchers at the Duke University Medical Center.
First Lady Michelle Obama visited a Washington, D.C. community health center Monday afternoon to announce the release of $851 million for the expansion and rehabilitation of clinics around the country, The New York Times reports.
HHS this week will issue proposed regulations to remove HIV from the list of "communicable diseases of public health significance," effectively lifting the ban on HIV-positive foreign residents from entering the country, Newsday reports (Reddy, 6/29). Last year, then-President George W. Bush signed into law a provision to remove HIV from the HHS list, the Washington Post"s blog, "44," reports. The proposed rule has to be published in the Federal Register, and then undergo a 45-day comment period before becoming finalized (Hsu, 6/29).
Oxfam Calls On G8 Leaders To Increase Agriculture Investment In Developing Countries
Los Angeles County Sheriff Lee Baca is considering expanding an eight-year-old program at Men"s Central Jail that distributes condoms in a unit for gay men, the Los Angeles Times reports. Under the program, an outreach worker from the nonprofit Center for Health Justice visits the jail once weekly to distribute about one condom per inmate to the unit"s 300 inmates. Baca is considering doubling the number of condoms being distributed. Sheriff Department officials acknowledge that HIV is a problem in county jails and spend about $2 million annually on HIV/AIDS medication and identify about 65 new cases of HIV each month, according to the Times. Steve Whitmore, a spokesperson for the Sheriff"s Department, said, "Sex in jails is against the law, but there is a public health issue that needs to be considered." A separate condom distribution program is being piloted at the California State Prison at Solano (Bloomekatz, Los Angeles Times 6/29).
UCB and Biogen Idec announced the discontinuation of the Phase II clinical trial of CDP323 for the treatment of relapsing multiple sclerosis (MS). Preliminary interim efficacy analysis showed that patients enrolled in this clinical trial did not benefit as expected from CDP323 compared to placebo after a six month treatment period. No cases of PML (progressive multifocal leukoencephalopathy) were noted.
Neural stem cells represent the cellular backup of our brain. These cells are capable of self-renewal to form new stem cells or differentiate into neurons, astrocytes or oligodendrocytes. Astrocytes have supportive functions in the environment of neurons, while oligodendrocytes form the myelin layer around axons in order to accelerate neuronal signal transmission. But how does a neural stem cell "know" which way it is supposed to develop? On the molecular level receptors of the Notch family play a significant role in this process. So far, only stimulating extracellular ligands of Notch receptors had been described. Biochemists of Goethe University Medical School now describe a long time assumed but not yet identified soluble Notch inhibitor.
Experts are predicting record-breaking temperatures this week, so it"s important to take precautions to ensure that your diabetes remains well-controlled in this extreme weather.
Whether on the trail, at the gym, or even on the front-porch steps, what happens inside your ankle in the milliseconds following a single misstep could sentence you to a lifetime of ankle trouble.
Wide gaps in quality outcomes for women persist, not only when compared to men, but among hospitals and states, according to a new study released by HealthGrades, the leading independent healthcare ratings organization. The Sixth Annual HealthGrades Women"s Health in American Hospitals study identifies patient outcomes for maternity care and inhospital treatment of 16 procedures/diagnoses concerning women"s health. Ratings for individual hospitals have been posted at www.healthgrades.com.
An observer feels more empathy for someone in pain when that person is in the same social group, according to new research in the July 1 issue of The Journal of Neuroscience. The study shows that perceiving others in pain activates a part of the brain associated with empathy and emotion more if the observer and the observed are the same race. The findings may show that unconscious prejudices against outside groups exist at a basic level.
Today, 15 new research projects aimed at bringing innovative medicines more quickly to the market have been selected to receive 246 million euros from the European Commission and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The projects will foster understanding of health issues such as diabetes, pain, severe asthma and psychiatric disorders while increasing drug safety. They will also help improve the training of researchers and clinicians involved in medicines development. The projects were chosen following the first call for proposals launched within the Innovative Medicines Initiative (IMI), a public-private partnership - so called Joint Technology Initiative- between the European Commission and the pharmaceutical industry. With this selection, IMI has reached a key milestone. This initiative marks the first time that pharmaceutical competitors are pooling their res, together with research organisations, patient groups and other stakeholders in large consortia, in order to develop generic, pre-competitive knowledge. The Commission"s contribution of €110 million is backed up with €136 million provided in-kind from the pharmaceutical industry. The successful projects will now enter into the final negotiation phase.
A new report from the Institute of Medicine recommends 100 health topics that should get priority attention and funding from a new national research effort to identify which health care services work best. It also spells out actions and res needed to ensure that this comparative effectiveness research initiative will be a sustained effort with a continuous process for updating priorities as needed and that the results are put into clinical practice.
People with ankle injuries who do not respond successfully to initial treatment may have a second chance at recovery, thanks to two new procedures developed to restore the injured area, according to a study published in the July 2009 issue of the Journal of the American Academy of Orthopaedic Surgeons (JAAOS).
The potential role of periodontitis, an inflammatory disease of the gums, in the risk of cardiovascular disease, particularly ischemic stroke, has received growing attention during the last decade. A new study is the first prospective cohort study to use clinical measures of periodontitis to evaluate the association between this disease and the risk of cerebrovascular disease. The study is published in Annals of Neurology, the official journal of the American Neurological Association
Researchers at the University of Michigan have devised a microscale tool to help them understand the mechanical behavior of biofilms, slimy colonies of bacteria involved in most human infectious diseases.
Deputy Executive Director and Chief Operating Officer, Amir Abdulla,
Diabetics undergoing total joint replacement often are at a higher risk of experiencing complications after surgery due to various pre-existing health conditions. According to a new study published in the July 2009 issue of The Journal of Bone and Joint Surgery (JBJS), those complications are less likely to occur when a diabetic patient has glucose levels under control.
Many low-income women are failing to take the hormonal therapy prescribed as part of their breast cancer treatment, possibly lowering their survival rates, according to a study led by a researcher in the Duke Comprehensive Cancer Center.
Despite rapid advances using a child"s own cord blood stem cells in regenerative therapies to repair damaged tissue due to injury or disease, most pregnant women today don"t learn about the ability to save their newborn"s cord blood. According to research published in the Journal of Reproductive Medicine, 3 out of every 4 pregnant women consider themselves only "minimally informed."
For the first time, scientists have shown that chromosomal abnormalities are present in more than 90% of IVF embryos, even those produced by young, fertile couples. Ms Evelyne Vanneste, a PhD student in the Centre for Human Genetics and the University Fertility Center, Leuven University, Belgium, told the 25th annual conference of the European Society of Human Reproduction and Embryology today (Wednesday July 1), that the surprising finding meant that current techniques used in preimplantation genetic screening (PGS), where embryos are screened genetically in order to select the best embryo for transfer, do nothing to improve pregnancy and live birth rates. Indeed, it can lead to potentially viable embryos being discarded, she said.
Survivors of childhood cancer run particular risks when pregnant and should be closely monitored, the 25th annual conference of the European Society of Human Reproduction and Embryology heard today (Wednesday 1 July). Dr. Sharon Lie Fong, of the Department of Obstetrics and Gynaecology, Erasmus MC University Medical Centre, Rotterdam, The Netherlands, said that, although such women may have conceived spontaneously and considered themselves to be perfectly healthy, their deliveries should always take place in a hospital.
One of the most controversial issues in men"s health is whether men should routinely have a blood test for prostate-specific antigen (PSA) to screen for prostate cancer. Some experts argue that PSA testing saves lives by helping detect this common form of cancer early. Others say it triggers unnecessary treatment that disrupts many more lives than it saves. The results of two studies released this spring focused the debate, but scientists are still a long way from concluding the discussion, reports the July 2009 issue of Harvard Men"s Health Watch.
On June 11, the National Institute for Health and Clinical Excellence
Researchers at Radboud University Medical Centre, together with UK
Researchers in New Mexico are reporting the surprise discovery that common table salt - so brittle that it crushes easily between a thumb and forefinger - becomes a super plastic in the weird environs of the nanoworld. The super-elastic salt can stretch like taffy to twice its original length without breaking. The discovery could lead to new insights into the role of salt in a wide variety of situations ranging from helping clouds to form to triggering asthmatic attacks in people, they say. Their study is in the current issue of ACS" Nano Letters, a monthly journal.
UCB announced that the U.S. Food and Drug Administration (FDA) approved Cimzia®, the only PEGylated anti-TNF (Tumor Necrosis Factor), for the treatment of adult patients with moderately to severely active rheumatoid arthritis (RA). Cimzia® can be dosed at 400 mg initially and at weeks two and four, followed by 200 mg every other week; for maintenance dosing, 400 mg every four weeks can be considered.
POZEN Inc. (NASDAQ:POZN), announced the submission of a New Drug Application (NDA) to the U.S. Food and Drug Administration (FDA) for the marketing approval of VIMOVO™ (PN 400), the combination of enteric coated (EC) naproxen and immediate release esomeprazole. POZEN and AstraZeneca entered into a global co-development agreement for VIMOVO in August 2006. Pending regulatory approval, the proposed trade name is VIMOVO and the proposed indications are for the signs and symptoms of osteoarthritis, rheumatoid arthritis and ankylosing spondylitis in patients who are at risk for developing NSAID-associated ulcers.
"In a major break with most other large companies, Wal-Mart Stores Inc. Tuesday told the White House that it supports requiring employers to provide health insurance to workers, a centerpiece of President Barack Obama"s effort to provide near-universal coverage to Americans," The Wall Street Journal reports. "Wal-Mart -- which provides insurance to employees and wants to level the playing field with companies that don"t -- on Tuesday delivered a letter to President Obama taking a different stance." The letter was signed by Wal-Mart Chief Executive Mike Duke, as well as Andrew Stern, president of the Service Employees International Union, and John Podesta, "who led President Obama"s transition team and is chief executive of the Center for American Progress, a liberal-leaning think tank." Wal-Mart"s new stance is "a shift from its previous stance on health-care overhaul and follows years of tussles with organized labor." The Journal adds a caveat: Wal-Mart "isn"t changing its policies. The company says it supports the employer mandate because all businesses should share the burden of fixing the health-care system. ... Wal-Mart"s support for a broad mandate also appears to be aimed at beating back an alternative that may be less favorable to the company. The Senate Finance Committee is considering a measure expected to result in a more burdensome health-insurance requirement for companies that have lower-wage workers" (Adamy and Zimmerman, 7/10).
A diverse international network has proposed to significantly increase the
Deadly diseases including plague, Ebola and Rift Valley Fever are being targeted as part of a new multi-million pound international partnership involving African researchers and the London International Development Centre (LIDC). The Southern African Centre for Infectious Disease Surveillance (SACIDS) links medical and veterinary institutions from five African countries and the UK to improve the capacity of African institutions to detect, identify and monitor infectious diseases affecting humans and animals, including new infectious human diseases of animal origin.
A human growth factor that stimulates blood stem cells to proliferate in the bone marrow reverses memory impairment in mice genetically altered to develop Alzheimer"s disease, researchers at the University of South Florida and James A. Haley Hospital found. The granulocyte-colony stimulating factor (GCSF) significantly reduced levels of the brain-clogging protein beta amyloid deposited in excess in the brains of the Alzheimer"s mice, increased the production of new neurons and promoted nerve cell connections.
University of Minnesota Medical School researcher Michael Mauer, M.D., has found a treatment that significantly slows the progression of eye injury in people with type 1 diabetes, a common complication caused by this disease. By administering an antihypertensive, medication commonly prescribed to treat high blood pressure, Mauer and colleagues were able to slow progression of diabetic eye damage in more than 65 percent of participants involved in the study.
Aging adults living in nursing homes and relying on the care of others are often susceptible to a long list of medical problems. These problems are debilitating for the residents and cost facilities millions of dollars. In a new study, a University of Missouri researcher found that long-term care facilities in Missouri saved more than $6 million in the past three years after implementing a quality care improvement program. Savings for the facilities were more than 10 times the program costs.
The American Dietetic Association has released an updated position paper on vegetarian diets that concludes such diets, if well-planned, are healthful and nutritious for adults, infants, children and adolescents and can help prevent and treat chronic diseases including heart disease, cancer, obesity and diabetes.
Deleting two genes in mice responsible for repairing DNA strands damaged by oxidation leads to several types of tumors, providing additional evidence that such stress contributes to the development of cancer. That"s the conclusion of a recent study* in DNA Repair by researchers at the National Institute of Standards and Technology (NIST), Oregon Health and Science University (OHSU) and the New York University School of Medicine (NYUSM).
The July issue of Ophthalmology, the journal of the American Academy of Ophthalmology, includes two studies that may influence clinical treatment of serious eye conditions. One study reports on silent cerebral infarcts (SCI) incidence and visual field loss in patients with normal-tension glaucoma; the other correlates inflammation biomarkers with corneal transplant rejection in herpes simplex patients.
The joint research, funded by the National Multiple Sclerosis Society and the UK MS Society as well as the National Institutes of Health and Howard Hughes Medical Institute, was conducted by scientists at the University of California San Francisco (UCSF) and University of Cambridge and was published in the journal Genes and Development.
A trio of genome-wide studies - collectively the largest to date - has pinpointed a vast array of genetic variation that cumulatively may account for at least one third of the genetic risk for schizophrenia. One of the studies traced schizophrenia and bipolar disorder, in part, to the same chromosomal neighborhoods.
A research team at Northwestern University has demonstrated a tool that can precisely deliver tiny doses of drug-carrying nanomaterials to individual cells.
Lixte Biotechnology Holdings (OTC Bulletin Board: LIXT) announced that investigators of the National Institute of Neurological Disorders and Stroke (NINDS) and the National Cancer Institute (NCI), National Institutes of Health and Lixte reported that its novel compound, LB-1.2, enhances the effectiveness of two standard chemotherapy drugs in mouse models of human cancers. This research is being conducted under a Cooperative Research and Development Agreement between NINDS and Lixte. The report was published online in the early edition (June 29) of the Proceedings of the National Academy of Science (US). The print version will appear July 14.
Acura Pharmaceuticals, Inc. (Nasdaq: ACUR) and King Pharmaceuticals, Inc. (NYSE: KG) announced today that the U.S. Food and Drug Administration (FDA) has issued a Complete Response Letter regarding the New Drug Application (NDA) for Acurox (oxycodone HC1, USP and niacin, USP) Tablets CII, an immediate release product intended for the relief of moderate-to-severe pain.
Prostate cancer patients who receive brachytherapy and remain free of disease for five years or greater are unlikely to have a recurrence at 10 years, according to a study in the July 1 issue of the International Journal of Radiation Oncology Biology Physics, the official journal of the American Society for Radiation Oncology (ASTRO).
Some Iowa groups are concerned that the state"s criminal HIV transmission law adds to the stigma associated with the virus and hampers testing efforts, and are urging lawmakers to revisit the law, the Iowa Independent reports. According to the Independent, criminal transmission of HIV is classified among the second-most serious felonies that can be committed in the state. Those that have been convicted under the law have been sentenced to a few months to several decades in prison. Former state Rep. Ed Fallon (D) who supported the 1998 law, said, "It seems to me that since it is now 11, almost 12, years later, it wouldn"t be [a] bad time to take a look at it again," adding that "surely [there] are some tweaks or changes that the legislature could consider relevant to this law, especially with all the new knowledge we have of the disease" (Waddington, 7/1).
Phill Wilson, CEO of the Black AIDS Institute (BAI), last week addressed the annual convention of the National Newspapers Publishers Association where he discussed the reasons blacks "were so slow to grasp the severity of the threat" of HIV, the NNPA/Seattle Medium reports. According to Wilson, many blacks believed that HIV/AIDS was not directly affecting their communities in the early years of the epidemic. In addition, he said when AIDS reached its peak between 1980 and 1982, blacks also were dealing with unemployment, poverty and welfare reform and, as a result, addressing HIV/AIDS was not a priority. Wilson also noted the reluctance by blacks to deal with the stigma related to the virus. Wilson said, however, "I"m more optimistic now around mobilizing black folks around HIV than [ever] before. I think we"ve made tremendous stride[s] and our institutions across the board are at a different place than they were" (Curry, 7/1).
The WHO on Wednesday announced plans for a clinical trial to test a new drug that "could halve the treatment period for river blindness [or onchocerciasis], a disease that threatens 100 million people mostly in Africa," AFP/Dow Jones Newswires/CNN Money reports (7/1). "This is a devastating illness that has plagued 30 African countries for centuries, in particular the populations in the most remote areas "beyond the end of the road,"" Uche Amazigo, director of the African Programme for Onchocerciasis Control (APOC), said (ANI/Thaindian.com, 7/1).
An Indian court on Thursday ruled that "gay sex between consenting adults was not a crime, ordering that the rights of citizens were violated by parts of a 150-year-old colonial-era law that made it illegal," Bloomberg reports. The law "has drawn criticism from public health activists as a barrier in the fight against HIV/AIDS" (Patnaik, 7/2).
The Wall Street Journal examines how some U.S.-based health care programs are improving their treatment capabilities by learning from strategies used in developing countries. "When doctors running the AIDS clinic at the University of Alabama at Birmingham wanted to increase the number of patients who showed up for treatment, they turned to an unusual place for help: southern Africa," Wall Street Journal writes. By using an AIDS clinic in Zambia as a model, the Alabama clinic was able to decrease its no-show rate "from 31% in 2007 to 18% through June 2009."
Economic Benefits Of Global Plan To Stop TB Examined
While CNN reports that the American Medical Association"s new president, J. James Rohack, is open to a government-funded health insurance option, others report that the system the AMA now endorses is not a public plan, but the heavily managed private plan that federal employees participate in.
The American Pharmacists Association (APhA) advises consumers to take acetaminophen products as recommended on the labeling and seek guidance from pharmacists or other healthcare providers on evaluating medication options. This recommendation comes as the Food and Drug Administration (FDA) convened a public advisory committee meeting on June 29 and June 30, 2009 regarding acetaminophen use in both over-the-counter (OTC) and prescription (Rx) products, the potential for liver injury, and potential interventions to reduce the incidence of liver injury.
"A year into a new effort to expand health coverage, recession-weary Marylanders are flocking to the state"s Medicaid program in numbers far greater than expected, costing the state $50 million more in the process," The Baltimore Sun reports. "As of this week, 44,255 additional state residents had enrolled in Maryland"s Medicaid system after income limits were significantly relaxed, outpacing projections that enrollment would increase by 26,605." Health advocates say "the state is doing the right thing by expanding publicly funded health care to adults who have children," but "increased enrollment has also enlarged the price tag." And "while the federal government picks up half the cost, the higher expenses come as Maryland is battling severe budget shortfalls. State health spending has been propped up this year by a major influx of stimulus dollars. Proponents had hoped to extend the public plan to adults without children this year, but the initiative was a victim of state budget constraints" (Fisher, 7/2).
Government Accountability Office Prescription Drugs: Overview of Approaches to Control Prescription Drug Spending in Federal Programs -- "The increasing cost of prescription drugs has put pressure to control drug spending on federal programs such as the Federal Employees Health Benefits Program (FEHBP), Medicare Part D, the Department of Veterans Affairs (VA), the Department of Defense (DOD), and Medicaid," according to a summary of a recent GAO report, where the office explores approaches used by the FEHBP and other federal programs to control prescription drug spending (6/24).
The NPA is working with LPCs and PCTs to develop a process for assuring the quality of commissioning of community pharmacy services. The aim of the project is to increase constructive dialogue between contractors and commissioners, increase the level of local investment in pharmacy services and improve PCT performance right the way around the commissioning cycle.
New research shows that 70 per cent of adults in the UK back proposals to protect children from tobacco by putting it out of sight in shops and 76 per cent support abolishing cigarette vending machines according to Cancer Research UK today (Wednesday) - on the second anniversary of the smoking ban in England.
The American Society of Radiologic Technologists announced it has released the first in a series of interactive learning modules focusing on computed tomography. CT Basics: Module 1 - Fundamentals provides in-depth information about the modality and its equipment and also offers radiologic technologists information about careers in CT. The first of 10 modules, the program features colorful images with easy-to-understand animations that engage participants in the learning process.