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Causes And Consequences - Caring For Patients With Intellectual Disability
Patients with developmental disabilities such as Down syndrome or cerebral palsy will benefit from a new online learning activity launched today by The Royal Australian College of General Practitioners (RACGP) to assist GPs to navigate the complex area of developmental disability.
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Neural Stem Cells Offer Potential Treatment For Alzheimer's Disease
UC Irvine scientists have shown for the first time that neural stem cells can rescue memory in mice with advanced Alzheimer"s disease, raising hopes of a potential treatment for the leading cause of elderly dementia that afflicts 5.3 million people in the U.S.
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Cruel And Inhuman Treatment Causes More Mental Damage Than Physical Torture
New research findings published by Dr Metin Basoglu, Head of Section of Trauma Studies at King"s College London and the Istanbul Centre for Behaviour Research and Therapy, examines the psychological impact of war captivity, "cruel, inhuman, and degrading treatment" (CIDT) and physical torture. Findings revealed that being held captive in a hostile and life-threatening environment, deprivation of basic needs, sexual torture, psychological manipulations, humiliation, exposure to extreme temperatures, isolation, and forced stress positions appear to cause more psychological damage than physical torture.
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UCLA Study Discovers Enzyme That Controls 'Bad' Cholesterol

BACKGROUND: Low-density lipoprotein (LDL) is the so-called "bad cholesterol" often linked to medical problems like heart disease and clogged arteries. Cells in the liver produce a specific receptor that sticks to LDL and removes it from the blood, lowering cholesterol levels. Statin drugs also reduce LDL cholesterol levels by boosting cells" production of the receptor. FINDINGS: Using a mouse model, UCLA scientists discovered a new mechanism that controls cells" production of LDL receptor. The team identified an enzyme called Idol that destroys the receptor, permitting more LDL cholesterol to circulate in the blood. In blocking Idol"s activity, the researchers triggered cells to make more receptor and absorb more cholesterol from the body. "We only know of three pathways that regulate the LDL receptor. The first two are already targeted by existing drugs," explained Dr. Peter Tontonoz, professor of pathology and laboratory medicine at the David Geffen School of Medicine at UCLA and an investigator at the Howard Hughes Medical Institute. "Idol is the first mechanism discovered in several years that may lead to a new medication designed to control cholesterol levels." IMPACT: The findings suggest that development of a drug that interferes with Idol"s activity could influence cholesterol metabolism and lower levels of bad cholesterol. Doctors could prescribe the new medication in conjunction with statin drugs, which also cut cholesterol levels by targeting a different enzyme linked to the LDL receptor. This could benefit patients that cannot tolerate statin-related side effects. AUTHORS: Tontonoz collaborated with Noam Zelcer, Cynthia Hong and Rima Boyadjian. The research was funded by the Howard Hughes Medical Institute and the National Heart, Lung and Blood Institute. Tontonoz and Zelcer have filed a patent related to the research findings. JOURNAL: The research appears in the June 11 online edition of the journal Science. Elaine Schmidt University of California - Los Angeles


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