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Two Reproductive Factors Are Important Predictors Of Death From Ovarian Cancer
Researchers from the Centers for Disease Control and Prevention (CDC) found that survival among women with ovarian cancer is influenced by age of menarche and total number of lifetime ovulatory cycles.
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Caffeic Acid Inhibits Colitis In A Mouse Model
Researchers at Iowa State University have found that increased expression of a form of cytochrome P-450 (CYP4B1) is a key marker of inhibition of colitis in mice by caffeic acid, an anti-inflammatory antioxidant compound widely distributed in foods. The results, which appear in the June 2009 issue of Experimental Biology and Medicine, implicate CYP4B1, a form of cytochrome P450 previously found to be associated with resolution of allergic inflammation in another model. The normalization of CYP4B1 by caffeic acid treatment was associated with significant lessening of colitic damage, assessed by examining colon histopathology. In comparison with rutin, an anti-inflammatory flavonoid and hypoxoside extract, a botanical known as African potato previously shown to protect against colitis, all three compounds had anti-inflammatory effects, suppressing myeloperoxidase, IL-17 and iNOS and increasing IL-4, known factors associated with inflammation responses. But only caffeic acid protected against the dextran sulfate sodium induced colitis. Its novel mechanism related to CYP4B1 is being studied further. The research team, Zhong Ye, a graduate student in Toxicology, along with Microbiology graduate students Zhiping Liu and Abigail Henderson, Visiting Scientist Kwangwon Lee, Korea University, Dr. Michael Wannemuehler, Veterinary Microbiology, Dr. Jesse Hostetter, a veterinary pathologist, and Dr. Suzanne Hendrich, Toxicologist and Nutritionist, performed studies in 8 week old mice fed the various dietary components and then exposed to dextran sulfate sodium in a mildly irritating dose to induce colitis. Dr. Hendrich noted that "this study of caffeic acid will help us to advance studies of botanicals and plant foods with respect to their ability and mechanisms of inhibiting colitis, and perhaps colon cancer, because colitis increases risk for this disease".
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Causes And Consequences - Caring For Patients With Intellectual Disability
Patients with developmental disabilities such as Down syndrome or cerebral palsy will benefit from a new online learning activity launched today by The Royal Australian College of General Practitioners (RACGP) to assist GPs to navigate the complex area of developmental disability.
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The Portable PT100 Noncontact Tonometer May Offer An Accurate And Convenient Alternative To Goldmann Applanation Tonometry

The portable noncontact PT100 tonometer provides intraocular pressure (IOP) measurements comparable to Gold applanation tonometry (GAT) within the normal range of IOP, according to a new article published online in Clinical Ophthalmology (published by Dove Medical Press). The results of the trail, which was carried out by Hamilton Eye Institute, University of Tennessee, demonstrates no significant difference between the two methods of measuring intraocular pressure (IOP). The comparability of the results recorded suggests the portable PT100 noncontact tonometer may provide a convenient and accurate means of measuring IOP in the community setting. However, comments about the article posted on the Society for Clinical Ophthalmology website, note practitioners" concerns about the correlation of measurements in the IOP ò‰¥20mmHg range. The importance of accurate IOP measurements above 20mmHg is of particular importance given the recent National Institute for Health and Clinical Excellence (NICE) glaucoma guidelines that recommend patients with IOP ò‰¥21mmHg should be referred to an ophthalmologist for further investigations. The study author, Professor Peter Netland, agreed that such concerns are entirely valid and warrant further investigation. The full article can be accessed through the Society for Clinical Ophthalmology"s website. The Society welcomes comments from eye care practitioners across all specialities. Society for Clinical Ophthalmology


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