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USC Researchers Identify DNA Mutation That Occurs At Beginning Point Of T-Cell Lymphoma
Researchers at the Keck School of Medicine of the University of Southern California (USC) have identified a key mechanism that causes chromosomes within blood cells to break - an occurrence that marks the first step in the development of human lymphoma.
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Senate Minority Leader McConnell Says He Will Oppose Sotomayor As Other Republicans Back Nominee
Senate Minority Leader Mitch McConnell (R-Ky.) on Friday announced that he will oppose Supreme Court nominee Sonia Sotomayor, even as increased Republican support seemed to ensure that she would be confirmed, the New York Times reports. McConnell said that he would not support Sotomayor"s nomination because her "record of written statements suggests an alarming lack of respect for the notion of equal justice, and, therefore, in my view, an insufficient willingness to abide by the judicial oath." McConnell intends to deliver the remarks to the Senate on Monday. Meanwhile, Republican Sens. Richard Lugar (Ind.), Mel Martinez (Fla.) and Olympia Snowe (Maine) said that they would support Sotomayor. The Times reports that the senators" backing of Sotomayor -- combined with her "solid Democratic support" -- shows that she should receive "strong confirmation approval" (Hulse, New York Times, 7/18). Senate Judiciary Committee Chair Patrick Leahy (D-Vt.) and ranking member Jeff Sessions (R-Ala.) would not predict how many Republicans could vote for her confirmation. Sessions said that Republicans are seeking a committee vote on Sotomayor on July 28, one week later than the date sought by committee Democrats. During that week, Republicans hope to review her record, her answers from her confirmation hearings and other responses to questions (AP/Boston Globe, 7/20).
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Hypoglycemia Increases Mortality Risk, Lengthens Hospital Stay For Diabetes Patients -- Even Outside The ICU
Diabetes patients who are hospitalized for non-critical illnesses, and develop hypoglycemia while hospitalized, are likely to remain hospitalized longer and face greater risk of mortality both during and after hospitalization, according to a study published in the July issue of Diabetes Care.
Diagnostics

Macular Degeneration: The 'See Food' Diet

Current research suggests that a diet high in omega-3 fatty acids may help prevent one of the leading causes of legal blindness among the elderly. The related report by Tuo et al, "A high omega-3 fatty acid diet reduces retinal lesions in a murine model of macular degeneration," appears in the August 2009 issue of the American Journal of Pathology. Age-related macular degeneration (AMD), loss of vision in the center of the visual field (macula) due to retinal damage, is one of the leading causes of legal blindness among the elderly. Approximately 10% of people from 66 to 74 years of age will develop some level of macular degeneration, making it difficult for them to read or even recognize faces. A diet high in omega-3 fatty acids has been found to protect against a variety of diseases including atherosclerosis and Alzheimer"s disease. Retrospective studies have suggested that diets high in fish oil or omega-3 fatty acids may also contribute to protection against AMD. A group led by Dr. Chi-Chao Chan at the National Eye Institute in Bethesda, MD examined the direct effect of omega-3 fatty acids on a mouse model of AMD. A diet with high levels of omega-3 fatty acids resulted in slower lesion progression, with improvement in some lesions. These mice had lower levels of inflammatory molecules and higher levels of anti-inflammatory molecules, which may explain this protective effect. Tuo et al suggest that "a diet enriched in EPA and DHA can ameliorate the progression of retinal lesions in their mouse model of AMD" and that "the results in these mice are in line with the epidemiological studies of AMD risk reduction by long chain n-3 fatty acids." The results "further provide the scientific basis for the application of omega-3 fatty acids and their biologically active derivatives in the prevention and treatment of AMD." In future studies, Dr. Chan and colleagues plan to use this murine model "to evaluate [other] therapies that might delay the development of AMD." Their ongoing projects include the "testing of systematic delivered pharmacochaperones and antioxidative molecules, as well as intraocularly delivered gene therapies." This work was supported by grants from The Intramural Research Program of the National Eye Institute, the National Institutes of Health, and the American Health Assistance Foundation. Tuo J, Ross RJ, Herzlich AA, Shen D, Ding X, Zhou M, Coon SL, Hussein N, Salem Jr N, Chan C-C: A high omega-3 fatty acid diet reduces retinal lesions in a murine model of macular degeneration. Am J Pathol 2009 175: 799-807 Angela Colmone American Journal of Pathology


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