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Gene Increases Risk Of Cancer
Scientists discover novel mechanism that increases the risk of common colorectal cancer
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New Survey Finds Majority Of Adults Don't Understand A Key Of High Blood Pressure
A new survey released shows that 3 out of 4 (75%) adults with high blood pressure are not at all familiar with the role of the renin system(1) -- a key regulator of blood pressure in the body.(2) Yet, about 9 out of 10 adults with high blood pressure (89%) both believe the condition is a cause for concern and want to understand what is going on in their body that is causing it.(1) The Omnibus survey, sponsored by Novartis Pharmaceuticals Corporation, was conducted by Harris Interactive(R) among more than 2,400 US adults ages 18+, more than 700 of whom said they have high blood pressure.(3)
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Can New Surgery Revolutionize Diabetes Treatment?
Metabolic surgery, a new surgical approach to metabolic disease, may provide the key to curing diabetes in some patients. This data was presented at the American Association of Clinical Endocrinologists (AACE) 18th Annual Meeting & Clinical Congress.
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Inflammation Clue To Fragile Bones In Muscular Dystrophy

Inflammation could contribute to bone loss in Duchenne"s muscular dystrophy (DMD), a discovery made by a group of Italian researchers. Dr Anna Rufo and her colleagues found that levels of an inflammatory molecule, known as IL-6, are high in patients with DMD. Duchenne"s muscular dystrophy is the most common of a group of genetic diseases when muscles become progressively weakened and wasted. It is caused by an abnormality of the dystrophin gene that is involved in the function of muscle cells. One in around 3,500 boys is affected. Little boys under the age of three will find walking, running and jumping difficult, and by the age of 11 they are unable to walk. "These children have very fragile bones that fracture easily," said Dr Rufo at the European Symposium on Calcified Tissues in Vienna today (25 May). "We thought that this was due to mechanical failure - the load on the bones - but felt sure that other factors were involved," she explained. The abnormal dystrophin gene causes muscle fibres to degenerate and become inflamed. As well as muscle damage, patients have osteoporosis and therefore a greater risk of fractures. Dr Rufo"s team at the University of L"Aquila found that children with DMD have increased levels of IL-6, a molecule that is also know to reduce bone formation and increase bone removal. In laboratory studies, the bone mass was reduced in dystrophin-deficient mice shown by the reduced bone forming cells (osteoblasts) and increased bone removal cells (osteoclast). When healthy osteoblasts were treated with sera collected from DMD patients they failed to mineralise the bone matrix and their IL-6 levels were increased. More than 100 other genes linked to osteoblast-osteoclast "cross-talk" were also affected. Their work is significant because glucocorticoids may be given to patients to help improve muscle strength and function for a short period of time. "Glucocorticoids are good for muscles in DMD but not so good for bones," said Dr Rufo. "Now we have found that osteoporosis in DMD patients could partly be explained by IL-6, we can try and find new ways to tackle inflammation," she concluded. Snell Communications Ltd


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