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Senate Bill To Protect Patients' Healthcare By Amending Medicare Coverage
The U.S. Senate has introduced a bill, S. 1221, "The Medicare Prompt Pay Correction Act," a companion bill to H.R. 1392, which was introduced in the U.S. House of Representatives and currently has 45 co-sponsors.
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Study Examines Trends In Gallbladder Cancer Over Four Decades
Overall prognosis for gallbladder cancer appears to be improving, although many patients still have incurable disease and poor survival rates, according to a report in the May issue ofArchives of Surgery, one of the JAMA/Archives journals.
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Democratic Senators Rally Support For Sotomayor; Hearing Witness List Released
Sens. Barbara Boxer (D-Calif.), Kirsten Gillibrand (D-N.Y.) and Amy Klobuchar (D-Minn.) held a press conference on Thursday to rally support for Supreme Court nominee Sonia Sotomayor, whose confirmation hearing in the Senate Judiciary Committee begins Monday, Roll Call reports. Boxer said that there is no need for abortion-rights groups and other women"s advocacy groups to publicly express their support for Sotomayor because the confirmation process has been progressing well. She said, "Things are going well. There"s no need to get involved." However, Boxer added that "foul play" by Republicans to delay the confirmation would prompt women"s organizations to more publicly advocate for Sotomayor (Brady, Roll Call, 7/9).Hearing Witness List Released The Senate Judiciary Committee on Thursday released witness lists for Sotomayor"s confirmation hearings, the New York Times reports. The Republicans" list includes Charmaine Yoest, president of the antiabortion-rights group Americans United for Life. Among Democrats" list is JoAnne Epps, dean of the Beasley School of Law at Temple University, on behalf of the National Association of Women Lawyers (Phillips, New York Times, 7/10).
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Genistein Targets MEK4 In Human Prostate Cancer Cells

Researchers have identified MEK4 as a pro-invasion protein and the target for genistein, a dietary compound, in prostate cancer cells, according to a new study published online July 28 in the Journal of the National Cancer Institute. Li Xu, M.D., Ph.D., and Raymond C. Bergan, M.D., of the Department of Medicine at Northwestern University in Chicago, and colleagues investigated the target for genistein in prostate cancer cells by assessing cell invasion and gene and protein expression of mitogen-activated protein kinase 4 (MEK4) and matrix metalloproteinase-2 (MMP-2), which is associated with cell invasion. Overexpression of MEK4 increased MMP-2 expression and cell invasion in prostate cancer cells; decreased MEK4 expression had the opposite effect. Computer modeling showed that genistein could bind to the active site of MEK4, and an enzymatic assay showed that genistein inhibited MEK4 kinase activity. The MMP-2 transcript level was statistically significantly higher in normal prostate epithelial cells, which are target cells for chemoprevention, from untreated patients with prostate cancer than from genistein-treated patients. "Thus, we have shown that it is possible to target motility-associated processes with genistein in patients with prostate cancer, have identified MEK4 as the therapeutic target for genistein in all six prostate cell lines examined, and have provided a possible mechanism to link high dietary consumption of genistein-containing foods with lower rates of prostate cancer metastasis and mortality," the authors write. Steve Graff Journal of the National Cancer Institute


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