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Eighth International Conference On Bipolar Disorder To Be Held In Pittsburgh, June 25 To 27
Nearly 1,000 researchers, clinicians and mental health advocates are expected to attend the Eighth International Conference on Bipolar Disorder, June 25 to 27, at the David L. Lawrence Convention Center in Pittsburgh. The event is held only once every two years and is the largest meeting of its kind solely devoted to bipolar disorder, a disease that affects almost six million Americans.
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Plexxikon Announces PLX4032 Phase 1 Data Showing Objective Responses In Metastatic Melanoma Patients
Plexxikon Inc. today announced preliminary data from a Phase 1 clinical study investigating PLX4032 (R7204). PLX4032 is a novel, oral and highly selective drug that targets the BRAFV600E cancer-causing mutation that occurs in most melanomas and about eight percent of all solid tumors. In patients whose cancer harbors this mutation and who were treated with therapeutic doses of PLX4032, tumor shrinkage and extended progression-free survival have been observed. Currently, two extension studies are being conducted in mutation-positive melanoma and colorectal cancer patients. Following the initial positive findings announced today, larger clinical trials to support a registration program for product approval are targeted to start later in 2009. Plexxikon and Roche are co-developing PLX4032 under their 2006 license and collaboration agreement.
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Stem Cell Transplant In Mouse Embryo Yields Heart Protection In Adulthood
Stem cells play a role in heart muscle rejuvenation by attracting cells from the body that develop into heart muscle cells. They have been successfully used to halt or reverse cardiac injury following heart attack, but not to prevent injury before it occurs.
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Finding Related To SIV In Monkeys Could Shed Light On HIV In Humans, Researchers Say

Researchers "believe they have found a "missing link" in the evolution of the virus that causes AIDS," based on findings from a study - published in the journal Nature - that examines simian immunodeficiency virus (SIV) in monkeys, the AP/Boston Globe reports (Borenstein, 7/23). The results of the study "contradict previous evidence suggesting that chimpanzees were immune from AIDS and that SIV infections in the species were harmless," according to the AP/Chicago Tribune (Mullen, 7/23). Researcher Beatrice Hahn of the University of Alabama at Birmingham said, "Our findings allow us to look at HIV from a new angle, comparing and contrasting chimpanzee and human infections." In addition, "She said that comparisons of the viruses that cause AIDS in chimpanzees and humans could lead to new insights into the responses of the immune systems in both species," the Times reports (Altman, New York Times, 7/22). This information was reprinted from dailyreports.kff.org with kind permission from the Henry J. Kaiser Family Foundation. You can view the entire Kaiser Daily U.S. HIV/AIDS Report, search the archives and sign up for email delivery at dailyreports.kff.org. © Henry J. Kaiser Family Foundation. All rights reserved.


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