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Pluristem Therapeutics Announces First Patient Enrollment In Phase I Clinical Trial For Treatment Of Peripheral Artery Disease With PLX-PAD
Pluristem Therapeutics Inc. (NasdaqCM:PSTI) (DAX:PJT), a bio-therapeutics company dedicated to the commercialization of unrelated donor-patient (allogeneic) cell therapy products for a variety of disorders, announced today that the first patient has been enrolled in a Phase I clinical trial of the Company"s allogeneic placental-derived adherent stromal cell product, termed PLX-PAD. PLX-PAD is being used in patients afflicted with critical limb ischemia (CLI), the end-stage of peripheral artery disease (PAD). The first patient was enrolled at the Franziskus-Krankenhaus Hospital, Berlin. The initiation of this study follows the recent approval of the Company"s Clinical Trial Application (CTA) to begin clinical trials with PLX-PAD by the Paul Ehrlich Institute (PEI), the German competent authority in the European Union. The Phase I study is designed to evaluate the safety of PLX-PAD in patients with CLI. A total of up to fifteen adults with the disease will be included in the trial which is being conducted at the Franziskus-Krankenhaus Hospital and Charitç© - Universitç¤tsmedizin Hospital, Berlin.
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Catastrophic Sports Injury Report Released
The National Center for Catastrophic Sports Injury Research based at the University of North Carolina at Chapel Hill has released its 26th annual all sports report.
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Cancer Survivors At Greater Risk Of Birth Complications; Special Monitoring Needed
Survivors of childhood cancer run particular risks when pregnant and should be closely monitored, the 25th annual conference of the European Society of Human Reproduction and Embryology heard today (Wednesday 1 July). Dr. Sharon Lie Fong, of the Department of Obstetrics and Gynaecology, Erasmus MC University Medical Centre, Rotterdam, The Netherlands, said that, although such women may have conceived spontaneously and considered themselves to be perfectly healthy, their deliveries should always take place in a hospital.
Oncology

Erectile Dysfunction Might Be Associated With Chronic Periodontal Disease: Two Ends Of The Cardiovascular Spectrum

UroToday.com - Together with Drs. Heruti, Bechor, Justo and Galor, we studied 815 Israeli male adults of whom 305 had complete data and were included in the statistical analysis. In the analyzed population, 2.1% of people without erectile dysfunction (ED) had advanced periodontal disease (defined as recession of periodontal bone of 6 mm or more) in comparison to 9.8% of the mild ED and 15.8% of the moderate/severe ED populations, respectively. However, due to the relatively small groups, we could not present the odds ratio. We are now planning a large-scale study to further establish the association between the two conditions. The proposed pathogenesis for this association is based on the previous findings of DNA of periodontal pathogenic bacteria in athermanous plaques and the epidemiological association between periodontal disease and coronary heart morbidity found in many world-wide large-scale studies. And since ED too was proven to be an early sign of coronary heart disease, it is reasonable to believe that extra-oral inflammation induced by periodontal bacteria might be associated with atherosclerosis and dysfunction of vessels first in the small vessels, such as the penile vasculature, and later in larger vessels such as the coronaries. Thus, as we conclude in the article, "CPD might be associated first with ED in young men and later with coronary artery disease in middle-aged men." Laboratory studies are needed, however, to confirm that hypothesis. Indeed, it is too early to make practical recommendations based on these initial results. However, the general population, as well as healthcare providers, have to remember that oral and periodontal health conditions as well as sexual function are both parts of individual well-being. Both conditions are linked to other serious diseases such as coronary heart disease and diabetes mellitus, thus the healthcare provider has to pay attention to early signs of impaired health or function and refer the patient for evaluation by the appropriate health care worker. Written by Yehuda Zadik, DMD MHA as part of Beyond the Abstract on UroToday.com UroToday - the only urology website with original content written by global urology key opinion leaders actively engaged in clinical practice. To access the latest urology news releases from UroToday, go to: www.urotoday.com Copyright: Medical News Today Not to be reproduced without permission of Medical News Today


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