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Vaccinating Children May Be Effective At Helping Control Spread Of Influenza
Targeting children may be an effective use of limited supplies of flu vaccine, according to research at the University of Warwick funded by the Wellcome Trust and the EU. The study suggests that, used to support other control measures, this could help control the spread of pandemics such as the current swine flu.
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Changing Paradigms In Hereditary Angioedema: A Focus On Timely Diagnosis And New Therapies
Hereditary angioedema (HAE) is an autosomal dominant disease affecting approximately 10,000 people in the United States. HAE causes recurrent attacks of intense localized edema involving the skin, airway, and visceral organs. While chronic therapy with attenuated androgens or plasmin inhibitors has been the mainstay of HAE therapy, many new therapies for prophylaxis and acute treatment are on the horizon. It is important for physicians to understand the signs and symptoms of patients who present with HAE and to be familiar with the conventional and emerging therapies available to treat them.
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Acceleron And Celgene Initiate Phase 2 Study Of ACE-011 To Treat Chemotherapy-Induced Anemia
Acceleron Pharma, Inc., a biopharmaceutical company developing novel therapeutics that modulate the growth of cells and tissues including red blood cells, bone and muscle, and Celgene Corporation (NASDAQ: CELG) announced the initiation of a second Phase 2 clinical study of ACE-011. This Phase 2 clinical trial is a randomized, double-blind, placebo-controlled study designed to evaluate the potential of ACE-011 to treat chemotherapy-induced anemia in patients with metastatic breast cancer. ACE-011 is a novel therapeutic agent that has been shown to increase levels of red blood cells and hemoglobin and stimulate new bone formation. ACE-011 works through a novel mechanism by inhibiting certain members of the TGF-beta superfamily while potentially avoiding the erythropoietin pathway.
Public Health

Clinical Handover - Critical Communications

The lead article in a special supplement on clinical handover in the Medical Journal of Australia relates a tragic case in which an elderly man died for want of effective handover. The ageing Indigenous man was evacuated to Katherine Hospital with pneumonia. The first failure in handover came when he travelled alone despite a previous recommendation from a doctor that he be accompanied by a family member because of his poor English and frail condition. After nine days" treatment he was flown back to the airstrip some distance from the town. A fax on his discharge was sent to the local community health facility, but it was not acted upon and there was no check in place with the travel service. The pilot left the patient at the airstrip, assuming someone was going to pick him up. Three days later the police were informed that he was missing. His body was subsequently found - he had died alone, dehydrated and suffering from pneumonia. This distressing event was related by Dr Christine Jorm and colleagues, of the Australian Commission on Safety and Quality in Health Care, to illustrate the human consequences of poor communication on handover. "Since this tragic incident, the Northern Territory Government has taken steps to standardise and improve handover processes but health professionals need to acknowledge that handover is alwaysň€¦ integral to the delivery of safe patient care," Dr Jorm said. Problems that can arise from poor communication at handover include incorrect medication, delays or failures in treatment, duplication of diagnostic testing and preventable readmissions. These failings waste time, strain health care res and cause harm to patients. The poor outcomes that arise from poor handover, and the scarcity of evidence, have motivated the Australian Commission on Safety and Quality in Health Care to develop evidence-based solutions for improving handover. Dr Jorm introduces a number of themes on the issue of handover that are explored in the MJA supplement, including the importance of clinical involvement in the quality improvement process and the need for "flexible standardisation". Medical Journal of Australia


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