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Link Between Successful Weight Loss And Vitamin D Levels
Vitamin D levels in the body at the start of a low-calorie diet predict weight loss success, a new study found. The results, which suggest a possible role for vitamin D in weight loss, were presented at The Endocrine Society"s 91st Annual Meeting in Washington, D.C.
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Embryology Study Offers Clues To Birth Defects
Gregg Duester, Ph.D., professor of developmental biology at Burnham Institute for Medical Research (Burnham), along with Xianling Zhao, Ph.D., and colleagues, have clarified the role that retinoic acid plays in limb development. The study showed that retinoic acid controls the development (or budding) of forelimbs, but not hindlimbs, and that retinoic acid is not responsible for patterning (or differentiation of the parts) of limbs. This research corrects longstanding misconceptions about limb development and provides new insights into congenital limb defects. The study was published online in the journal Current Biology on May 21.
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World Leaders Must Take Action To Support Commitments To Lower Maternal Mortality, Opinion Piece Says
"I stood up and applauded for women everywhere when I heard the news" that the United Nations Human Rights Council, including the U.S., "recognized maternal death as a human rights issue," CARE President and CEO Helene Gayle writes in an Atlanta Journal-Constitution opinion piece. Gayle writes that governments for the past 15 years "have failed to meet the commitments made and targets set to reduce the more than half a million maternal deaths every year."According to Gayle, preventing maternal death "requires three well-coordinated actions: sustain political leadership, secure adequate res and strengthen health systems." She adds that the resolution "is a positive step" but that it is "only effective if it translates into action." She continues, "It"s great to see the Obama administration places women and girls high on the agenda," adding that many members of Congress also support these issues.Reducing maternal mortality "requires significant res," Gayle writes. She adds, "To be blunt, an estimated global commitment of $39 billion over 10 years is needed to make significant progress." Such a commitment would be "an investment in women, their families and the economic productivity of nations," according to Gayle."The cost of not investing is far greater," Gayle continues. She notes that women "do two-thirds of the world"s work and produce nearly 60% of the world"s food." In addition, "children who lose their mothers are 10 times more likely to die in childhood than children with mothers," and maternal and newborn deaths "represent an estimated annual loss of $15.5 billion in productivity," according to Gayle. "Clearly, other development goals cannot be met without healthy mothers," she adds.She continues that the "most tragic and infuriating point" is that the "death of a woman in childbirth is one of the most inexcusable deaths on earth." Because high maternal mortality is a "barometer of weak health systems, often reflecting the low status of women," strengthening health systems to improve maternal health will therefore enable the system to "address other health needs," Gayle writes. She adds that countries such as Bangladesh, Ethiopia and Peru have improved mortality rates "through four lifesaving programs: family planning, skilled and culturally sensitive care during pregnancy and childbirth, emergency care for complications and postpartum care."Gayle writes, "The U.S. can spearhead a comprehensive maternal health action plan and, by doing so, set an example for world leaders to join and invest in." She concludes, "The actions we take now can make maternal death a problem of the past and not one of our children"s future" (Gayle, Atlanta Journal-Constitution, 7/10).
Endocrinology

Brain Activity Stablilized By Dynamic Molecular Mechanism

In the brain, many types of synaptic proteins are spatio-temporally regulated to maintain synaptic activity at a constant level. Here, the Japanese research group led by Professor Masaki Fukata, Drs. Yuko Fukata and Jun Noritake in National Institute for Physiological Sciences, Japan, found that two types of palmitoylating enzymes finely-tune the location and function of a major synaptic protein, PSD-95, in different ways. They also found that this mechanism contributes to keeping synaptic activity stable when synaptic activity dynamically changes. The Japan Science and Technology Agency (JST) supported this study. They report the finding in Journal of Cell Biology published on July 13, 2009. The research group focused on two types of palmitoylating enzymes, DHHC2 and DHHC3. Protein palmitoylation, the most common lipid modification with the 16-carbon fatty acid palmitate, provides an important mechanism for regulating synaptic proteins in neurons. Here, the research group found that DHHC3 is located in the cell body of neurons to palmitoylate newly synthesized synaptic proteins such as PSD-95, and move out them into dendrites of neurons. In contrast, DHHC2 are located mainly in dendrites of neurons. Dendritically localized DHHC2 mediates dynamic palmitoylation of PSD-95 at synapses upon extracellular signals. When synaptic activity decreases, DHHC2 translocates to the synaptic site to facilitate palmitoylation of synaptic proteins to keep synaptic activity at a constant level. "We have already found 23 types of palmitoylating enzymes. Our finding suggests that individual palmitoylating enzymes have distinct functions in neurons. Some of palmitoylating enzymes are known to be differently related to neurological disorders such as mental retardation, schizophrenia and Huntington"s disease. Therefore, this palmitoylating enzyme family may represent exciting therapeutic targets", said Professor Fukata. Masaki Fukata National Institute for Physiological Sciences


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