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Risk Factors Of Cardiovascular Disease Rising In Poor, Young
Cardiovascular disease is increasing in adults under 50 and those of lower socioeconomic status, despite recent trends which show that cardiovascular disease is declining in Canada overall, say researchers at the Peter Munk Cardiac Centre. Untreated cardiovascular disease can lead to heart failure, coronary artery disease and death, and is the most common cause of hospitalization in North America.
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Illumina Launches Multi-Sample Indexing For GoldenGate(R) Assay
Illumina, Inc. (NASDAQ:ILMN) launched GoldenGate Indexing, a high-throughput genotyping solution that utilizes multi-sample indexing technology. Researchers may now screen up to 16 times as many samples per reaction as the standard GoldenGate Assay, increasing throughput from 288 samples per day to greater than 2000, while decreasing total reagent consumption. This high-quality genotyping system includes automation control and positive sample tracking through an Illumina Laboratory Information Management System (LIMS), creating a turnkey solution for low-complexity screening at an affordable cost per sample. The plexity ranges include 96-plex, 192-plex and 384-plex, which are ideal for screening in the livestock and agriculture market as well as for whole-genome association target validation and quality control applications.
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After Menopause, Hormone Therapy Plus Physical Activity Reduce Belly Fat, Body Fat Percentage
Older women who take hormone therapy to relieve menopausal symptoms may get the added benefit of reduced body fat if they are physically active, according to a new study. The results were presented at The Endocrine Society"s 91st Annual Meeting in Washington, D.C.
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Blood Flow In Alzheimer's Disease

Dr. Jennifer C Palmer and colleagues at the University of Bristol have discovered that endothelin converting enzyme-2 (ECE-2) may cause the decrease in cerebral blood flow seen in Alzheimer"s disease. These results are presented in the July 2009 issue of the American Journal of Pathology. Alzheimer"s disease is the most common form of dementia. Aí² peptide, which accumulates in the brain of Alzheimer"s disease patients, is thought to lead to tightening of the blood vessels and reduction of cerebral blood flood. ECE-2 may contribute to these symptoms by converting an inactive precursor to endothelin-1, which constricts blood vessels. To determine if ECE-2 affects cerebral blood flow in Alzheimer"s disease, Palmer et al examined the expression of ECE-2. They found that ECE-2 levels were elevated in patients with Alzheimer"s disease and that Aí² could increase ECE-2 expression in vitro. These data indicate that ECE-2 levels are increased in response to Aí² and may cause the decrease in cerebral blood flow seen in Alzheimer"s disease. Palmer et al "suggest that [endothelin-1] receptor antagonists, already licensed for treating other diseases, could be of benefit in [Alzheimer"s disease] therapies." Palmer JC, Baig S, Kehoe PG, Love S: Endothelin-Converting Enzyme-2 is Increased in Alzheimer"s Disease. Am J Pathol 2009, 174: 2672-2680 Angela Colmone American Journal of Pathology


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