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BioSante Pharmaceuticals Comments On Study Showing No Increased Risk Of Breast Cancer In Women Using Testosterone For Low Libido

BioSante Pharmaceuticals, Inc. (NASDAQ: BPAX), which is developing a testosterone gel (LibiGel®) to treat hypoactive sexual desire disorder (HSDD) in women, is pleased to comment on results in a paper published in the July issue of The Journal of Sexual Medicine showing testosterone has no effect on the incidence of invasive breast cancer among menopausal women who use testosterone to improve sexual function. The study, led by Susan Davis, M.D. of the Women"s Health Program, Department of Medicine at Alfred Hospital in Australia, evaluated 631 women treated with testosterone between January 1989 and December 2007 in a clinical endocrinology practice. In the report the use of testosterone therapy was not associated with a statistically significant increase in the risk of breast cancer compared to their control population, and that testosterone exposure did not increase breast cancer risk. "These findings are another significant and reassuring set of data indicating the safety of testosterone in the treatment of hypoactive sexual desire disorder," said Michael C. Snabes, M.D., Ph.D, BioSante"s vice president, clinical development. "Recently BioSante reported positive safety data from our Phase III Cardiovascular and Breast Cancer Safety Study showing an exceptionally low number of cardiovascular adverse events. In addition to this safety study, we are conducting two LibiGel Phase III efficacy trials under an FDA agreed SPA. LibiGel is the only pharmaceutical product in the U.S. in active development for the treatment of HSDD in menopausal women. We believe LibiGel can be the first product the FDA approves for this indication. We expect to be able to submit a New Drug Application by the middle of 2011." The authors of the published paper reviewed medical records of all women in a single practice treated with testosterone for loss of sexual desire over the course of nearly nine years. The mean age of the women at the start of therapy was 49.1. Women used testosterone for a median of 1.3 years, and were followed for an average of 6.7 years, with a total of 4,015 woman-years of follow-up. The incidence rate of invasive breast cancer was 299 cases/100,000 person-years, which is very similar to the rate reported for hormone therapy non-users in the U.S. Nurses Health Study (295/100,000 women-years). As previously announced by BioSante, treatment with LibiGel in a Phase II clinical trial significantly increased satisfying sexual events in surgically menopausal women suffering from FSD. The Phase II trial results showed LibiGel significantly increased the number of satisfying sexual events by 238 percent versus baseline (pBioSante Pharmaceuticals, Inc.


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