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Eighth International Conference On Bipolar Disorder To Be Held In Pittsburgh, June 25 To 27
Nearly 1,000 researchers, clinicians and mental health advocates are expected to attend the Eighth International Conference on Bipolar Disorder, June 25 to 27, at the David L. Lawrence Convention Center in Pittsburgh. The event is held only once every two years and is the largest meeting of its kind solely devoted to bipolar disorder, a disease that affects almost six million Americans.
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Thirteen Single-Payer Activists Settle Their Cases After Disrupting Hearing
Thirteen people charged with "disruption of Congress" for standing and shouting pro-single-payer system slogans during a health care reform committee hearing settled their cases, The Great Falls (Mont.) Tribune reports.
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Diabetes UK Shortlisted For Third Sector Excellence Awards
The Diabetes UK Media Relations Team has been shortlisted as one of five finalists for The Third Sector Excellence Awards in the category of Communications Team.
Oncology

A Breakthrough In Gastric Carcinogenesis

Checkpoint with forkhead and ring finger (CHFR) is a mitotic stress checkpoint gene whose promoter is frequently methylated in various kinds of cancer. In gastric cancer, CHFR promoter hypermethylation has been reported to lead to chromosome instability (CIN) and genetic instability is one of the hallmarks of human cancer. A research team led by Dr Eiji Oki from Kyushu University examined the methylation status of the promoter region of CHFR and microsatellite instability (MIN) status in primary gastric cancers. Their study was published on May 28, 2009 in the World Journal of Gastroenterology. They investigated the promoter methylation of CHFR in 59 cases of gastric cancer using methylation-specific PCR. Five microsatellite loci were analyzed using high-intensity microsatellite analysis reported previously, and p53 gene mutations were investigated by direct sequencing. They found that twenty cases (33.9%) showed promoter methylation and no relation was observed with the clinicopathological factors. The promoter methylation of CHFR was frequently accompanied with MIN. Seven of 20 (35.0%) cases showed MIN in hypermethylation of the CHFR tumor, while three of 39 (7.7%) cases showed MIN in the non-methylated CHFR tumor (P World J Gastroenterol 2009; 15(20): 2520-2525. Correspondence to: Eiji Oki, MD, PhD, Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1, Maidashi, Higashi-ku, Fukuoka 812-8582, Japan. Lai-Fu Li World Journal of Gastroenterology


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